ArticleMolecular and cellular biology1999
Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- The bxd PRE from Bithorax Complex of Drosophila melanogaster Has Weak Insulator Activity.Doklady. Biochemistry and biophysics · 2025Article
- Review
- Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator.Epigenetics & chromatin · 2019Article
- DNA sequence models of genome-wide Drosophila melanogaster Polycomb binding sites improve generalization to independent Polycomb Response Elements.Nucleic acids research · 2019Article
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Chromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immuno-osseous dysplasia.Nucleus (Austin, Tex.) · 2016Article
- Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.Cellular and molecular life sciences : CMLS · 2014Review
- Histone methylation in the nervous system: functions and dysfunctions.Molecular neurobiology · 2013Review
- TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.Cell · 2012Article
- Histone methylation: a dynamic mark in health, disease and inheritance.Nature reviews. Genetics · 2012Review
- The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.Annual review of biochemistry · 2012Review
- Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways.Development (Cambridge, England) · 2009Article
- A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region.Molecular and cellular biology · 2007Article
- In situ dissection of a Polycomb response element in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins.Genes & development · 2006Article
- Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic.Molecular and cellular biology · 2006Article
- From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module.The EMBO journal · 2004Article
- ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.British journal of cancer · 2004Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, two classes of genes, the trithorax group and the Polycomb group, are required in concert to maintain gene expression by regulating chromatin structure. We have identified Trithorax protein (TRX) binding elements within the bithorax complex and have found that within the bxd/pbx regulatory region these elements are functionally relevant for normal expression patterns in embryos and confer TRX binding in vivo. TRX was localized to three closely situated sites within a 3-kb chromatin maintenance unit with a modular structure. Results of an in vivo analysis showed that these DNA fragments (each approximately 400 bp) contain both TRX- and Polycomb-group response elements (TREs and PREs) and that in the context of the endogenous Ultrabithorax gene, all of these elements are essential for proper maintenance of expression in embryos. Dissection of one of these maintenance modules showed that TRX- and Polycomb-group responsiveness is conferred by neighboring but separable DNA sequences, suggesting that independent protein complexes are formed at their respective response elements. Furthermore, we have found that the activity of this TRE requires a sequence (approximately 90 bp) which maps to within several tens of base pairs from the closest neighboring PRE and that the PRE activity in one of the elements may require a binding site for PHO, the protein product of the Polycomb-group gene pleiohomeotic. Our results show that long-range maintenance of Ultrabithorax expression requires a complex element composed of cooperating modules, each capable of interacting with both positive and negative chromatin regulators.
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