ArticleMolecular and cellular biology1999
Activation of RNA polymerase III transcription in cells transformed by simian virus 40.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
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- Host Noncoding Retrotransposons Induced by DNA Viruses: a SINE of Infection?Journal of virology · 2017Review
- Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma.Arthritis research & therapy · 2014Article
- RNA polymerase III transcription in cancer: the BRF2 connection.Molecular cancer · 2011Review
- Cell-cell contact regulates gene expression in CDK4-transformed mouse podocytes.American journal of physiology. Renal physiology · 2010Article
- Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.Molecular cancer · 2010Article
- Apoptotic regulation and tRNA.Protein & cell · 2010Review
- tRNA and cytochrome c in cell death and beyond.Cell cycle (Georgetown, Tex.) · 2010Review
- Regulation of TFIIIB during F9 cell differentiation.BMC molecular biology · 2010Article
- Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.Nucleic acids research · 2010Article
- Article
- PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription.Journal of molecular signaling · 2007Article
- A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC.Nucleic acids research · 2006Article
- Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus.Oncogene · 2005Article
- RNA polymerase III transcription and cancer.Oncogene · 2004Review
- CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA polymerase (Pol) III transcription is abnormally active in fibroblasts that have been transformed by simian virus 40 (SV40). This report presents evidence that two separate components of the general Pol III transcription apparatus, TFIIIB and TFIIIC2, are deregulated following SV40 transformation. TFIIIC2 subunits are expressed at abnormally high levels in SV40-transformed cells, an effect which is observed at both protein and mRNA levels. In untransformed fibroblasts, TFIIIB is subject to repression through association with the retinoblastoma protein RB. The interaction between RB and TFIIIB is compromised following SV40 transformation. Furthermore, the large T antigen of SV40 is shown to relieve repression by RB. The E7 oncoprotein of human papillomavirus can also activate Pol III transcription, an effect that is dependent on its ability to bind to RB. The data provide evidence that both TFIIIB and TFIIIC2 are targets for activation by DNA tumor viruses.
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