ArticleMolecular and cellular biology1999
p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- CtIP is essential for early B cell proliferation and development in mice.The Journal of experimental medicine · 2019Article
- Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice.Blood · 2012Article
- SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus.Journal of virology · 2011Article
- Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus.Journal of virology · 2008Article
- Inhibition of TFII-I-dependent cell cycle regulation by p53.Molecular and cellular biology · 2005Article
- Decreased virus population diversity in p53-null mice infected with weakly oncogenic Abelson virus.Journal of virology · 2005Article
- p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis.Journal of virology · 2004Article
- B cell development and immunoglobulin transcription in Oct-1-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells.Journal of virology · 2004Article
- Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism.Molecular and cellular biology · 2003Article
- Absence of p53 complements defects in Abelson murine leukemia virus signaling.Journal of virology · 2003Article
- Childhood leukemia: electric and magnetic fields as possible risk factors.Environmental health perspectives · 2003Review
- Review
- NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.Molecular and cellular biology · 2002Article
- P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity.Molecular and cellular biology · 2002Article
- Modeling Philadelphia chromosome positive leukemias.Oncogene · 2001Review
- Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model.Journal of virology · 2001Article
- Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Transformation of pre-B cells by Abelson murine leukemia virus (Ab-MLV) involves a balance between positive, growth-stimulatory signals from the v-Abl oncoprotein and negative regulatory cues from cellular genes. This phenomenon is reflected by the clonal selection that occurs during Ab-MLV-mediated transformation in vivo and in vitro. About 50% of all Ab-MLV-transformed pre-B cells express mutant forms of p53 as they emerge from this process, suggesting that this protein may play an important role in the transformation process. Consistent with this idea, expression of p19(Arf), a protein whose function depends on the presence of a functional p53, is required for the apoptotic crisis that characterizes primary Ab-MLV transformants. To test the role of p53 in pre-B-cell transformation directly, we examined the response of Trp53(-/-) mice to Ab-MLV. The absence of p53 shortens the latency of Abelson disease induction but does not affect the frequency of cells susceptible to Ab-MLV-induced transformation. However, primary transformants derived from the null animals bypass the apoptotic crisis that characterizes the transition from primary transformant to fully malignant cell line. These effects do not require p21(Cip-1), a major downstream target of p53; however, consistent with a role of p19(Arf), transformants expressing mutant p53 and abundant p19 retain wild-type p19 sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.