ArticleMolecular and cellular biology1999
Major Egr3 isoforms are generated via alternate translation start sites and differ in their abilities to activate transcription.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.Molecular psychiatry · 2022Article
- Escalated Oxycodone Self-Administration and Punishment: Differential Expression of Opioid Receptors and Immediate Early Genes in the Rat Dorsal Striatum and Prefrontal Cortex.Frontiers in neuroscience · 2019Article
- Expression ofAsian-Australasian journal of animal sciences · 2017Article
- Article
- Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes.PloS one · 2014Article
- Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses.The American journal of pathology · 2013Article
- The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells.PloS one · 2010Article
- Novel forms of Paired-like homeodomain transcription factor 2 (PITX2): generation by alternative translation initiation and mRNA splicing.BMC molecular biology · 2008Article
- Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory.Molecular and cellular neurosciences · 2007Article
- Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.Molecular and cellular biology · 2005Article
- Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.The Biochemical journal · 2003Article
- Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain.Journal of virology · 2002Article
- A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Mechanism of measles virus failure to activate NF-kappaB in neuronal cells.Journal of neurovirology · 2001Article
- Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the egr family of transcription regulatory factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In previous studies, we detected a major, unidentified Egr response element (ERE) binding complex in brain extracts. We now report that this complex contains a truncated isoform of Egr3 generated by use of an alternate translation start site at methionine 106. Furthermore, the ERE binding complex previously thought to contain full-length Egr3 includes several isoforms generated by initiation at other internal methionines. Full-length and truncated (missing residues 1 to 105) Egr3 isoforms differ in the ability to stimulate transcription directed by a tandem repeat of two EREs but not by a single ERE. Taken together, our results indicate that alternative translation start sites are used to generate Egr3 isoforms with distinct transcriptional properties.
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