Trial reportArchives of disease in childhood1999
Persistent nocturnal cough: randomised controlled trial of high dose inhaled corticosteroid.
Trial report in Archives of disease in childhood, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Inhaled corticosteroids for subacute cough in children.The Cochrane database of systematic reviews · 2013Pooled it
- Indoor air modification interventions for prolonged non-specific cough in children.The Cochrane database of systematic reviews · 2006Pooled it
- Inhaled corticosteroids for non-specific chronic cough in children.The Cochrane database of systematic reviews · 2005Pooled it
- Inhaled beta2-agonists for treating non-specific chronic cough in children.The Cochrane database of systematic reviews · 2005Pooled it
- ERS guidelines on the diagnosis and treatment of chronic cough in adults and children.The European respiratory journal · 2020Article
- KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea.Allergy, asthma & immunology research · 2018Review
- Analysis of the Literature on Chronic Cough in Children.The open respiratory medicine journal · 2017Review
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- Very high dose inhaled corticosteroids: panacea or poison?Archives of disease in childhood · 2006Review
- Neutrophil airway inflammation in childhood asthma.Thorax · 2006Article
- Establishing a gold standard for manual cough counting: video versus digital audio recordings.Cough (London, England) · 2006Article
- Cough: are children really different to adults?Cough (London, England) · 2005Article
- [Chronic cough in childhood].Revue des maladies respiratoires · 2004Review
- Cough . 2: Chronic cough in children.Thorax · 2003Review
- Difficult asthma in children.Thorax · 2002Review
- Acute upper airway infections.British medical bulletin · 2002Review
- Parents' interpretations of children's respiratory symptoms on video.Archives of disease in childhood · 2001Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of a short course of inhaled corticosteroid in the treatment of isolated and persistent nocturnal cough in children.
designRandomised double blind placebo controlled study.
settingSubjects' homes in east London, England. SUBJECTS: Consecutively referred children, 1-10 years old, with persistent nocturnal cough.
interventionsPlacebo or fluticasone propionate 1 mg twice daily for three nights and 500 microg twice daily for 11 nights. Videotaping of children at night: two nights' baseline, nights 3 and 4 after three days of inhaled corticosteroid, and nights 15 and 16.
main outcome measureA fall in 75% of coughs from baseline.
results50 subjects were recruited. The median number of coughs in the baseline period for the inhaled corticosteroid group and placebo group were 92 and 71, respectively (p = 0.43) and, on nights 15 and 16, 8 and 36, respectively (p < 0. 01). Compared to baseline, both groups of subjects improved significantly by nights 15 and 16 (p < 0.01; p < 0.01). Comparing the inhaled corticosteroid and placebo groups, coughs fell to a median of 22% and 57% of baseline totals on nights 3 and 4, respectively (p = 0.38), and 8% and 35% on nights 15 and 16, respectively (p = 0.02). 17 of 24 subjects on inhaled corticosteroid who completed the study and 8 of 23 on placebo improved by 75% after two weeks (p = 0.03).
conclusionsChildren with persistent nocturnal cough improve in two weeks after referral on placebo. There is a modest benefit from a two week course of high dose inhaled corticosteroid.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.