Evidence map›Paper›PMID 10371465›Full record

ReviewMolecular neurobiology1999

New perspectives in the functional role of GABA(A) channel heterogeneity.

S Vicini

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Regulation of GABATrends in neurosciences · 2021
    Review
  3. Role of GABAMolecular brain · 2017
    Review
  4. Molecular pharmacology · 2017
    Article
  5. Article
  6. Article
  7. GABA-A receptor inhibition of local calcium signaling in spines and dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Article
  8. Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor α subunit isoforms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  9. Stress, ethanol, and neuroactive steroids.Pharmacology & therapeutics · 2007
    Review
  10. Review
  11. Article
  12. Article
  13. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003
    Article
  14. GABA receptors containing Rdl subunits mediate fast inhibitory synaptic transmission in Drosophila neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003
    Article
  15. Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

S ViciniDepartment of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA.
Georgetown University · US

Funding

NINDS NIH HHS K04 NS01680NINDS NIH HHS R01 NS32759
6 · The paper itself

Abstract

Gamma-aminobutyric acid A (GABA(A)) channels responsible for inhibitory synaptic transmission possess a consistent heterogeneity of structure in terms of distinct constitutive subunits. During the past 10 years, considerable progress has been made in understanding the magnitude of this large diversity. Structural requirements for clinically important drugs such as benzodiazepines and barbiturates have been elucidated, and the anatomical distribution in distinct neuronal populations and the developmental profiles of individual subunits have been elucidated with various techniques. However, the relevance of subunit heterogeneity to synaptic transmission is still largely lacking. Recently, substantial progress has been achieved in understanding the crucial role of desensitization as a molecular determinant in defining the duration and frequency responses of inhibitory synaptic transmission. This development, together with a combination of different experimental approaches, including patch-clamp recordings and ultrafast agonist applications in brain slices and mammalian cells expressing recombinant GABA(A) receptor, has begun to shed light on a possible role for subunit composition of synaptic receptors in shaping the physiological characteristics of synaptic transmission. Nowhere else in the central nervous system is the anatomical and developmental profile of GABA receptor heterogeneity as well understood as it is in the cerebellum. This review summarizes advances in the understanding of functional correlates to subunit heterogeneity in the cerebellum relevant for inhibitory synaptic function.

Indexed as

AnimalsBarbituratesBenzodiazepinesBrainCerebellumHumansReceptors, GABA-ASynapsesSynaptic TransmissionBarbituratesBenzodiazepinesReceptors, GABA-A

Identifiers

PMID10371465
OpenAlexW2081602197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.