ArticleThe EMBO journal1999
Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 137 citations in OpenAlex.
- The isolatedbioRxiv : the preprint server for biology · 2026Article
- Recent Advances in the Understanding of Gonadotrope Lineage Differentiation in the Developing Pituitary.Neuroendocrinology · 2025Review
- PITX1 plays essential functions in cancer.Frontiers in oncology · 2023Review
- FSHB Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism.Endocrinology · 2021Article
- Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.Molecular endocrinology (Baltimore, Md.) · 2015Article
- PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia.Cell cycle (Georgetown, Tex.) · 2014Article
- Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1.International journal of molecular sciences · 2013Article
- Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Functional conservation of Drosophila FTZ-F1 and its mammalian homologs suggests ligand-independent regulation of NR5A family transcriptional activity.Development genes and evolution · 2013Article
- Cold-shock-domain protein A (CSDA) contributes posttranscriptionally to gonadotropin-releasing hormone-regulated expression of Egr1 and indirectly to Lhb.Biology of reproduction · 2012Article
- The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription.Molecular and cellular biology · 2010Article
- Genetic regulation of pituitary gland development in human and mouse.Endocrine reviews · 2009Review
- SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.Molecular and cellular biology · 2009Article
- Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Conservation of mechanisms mediating gonadotrophin-releasing hormone 1 stimulation of human luteinizing hormone beta subunit transcription.Molecular human reproduction · 2009Article
- Pituitary homeobox 2 regulates adrenal4 binding protein/steroidogenic factor-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Welcoming beta-catenin to the gonadotropin-releasing hormone transcriptional network in gonadotropes.Molecular endocrinology (Baltimore, Md.) · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ptx1 (Pitx1) is a bicoid-related homeobox transcription factor expressed from the onset of pituitary development. It was shown to cooperate with cell-restricted factors, such as Pit1, NeuroD1/PanI and steroidogenic factor 1 (SF-1), to establish a combinatorial code conferring lineage- and promoter-specific gene transcription in the pituitary. Transcriptional synergism between Ptx1 and SF-1 on two SF-1 target genes, pituitary luteinizing hormone beta and Müllerian-inhibiting substance (MIS), requires SF-1 binding to DNA and appears to result from direct physical interaction between these two proteins. The interaction between the C-terminus of Ptx1 and the N-terminal half of SF-1 results in transcriptional enhancement that equals the activity of a constitutively active SF-1 mutant and that may mimic the effect of a still unidentified SF-1 ligand. Thus, the unmasking of SF-1 activity by Ptx1 may represent a developmental mechanism to alleviate the need for SF-1 ligand in transcription and, possibly, at critical times during organogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.