ArticleThe EMBO journal1999
Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
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- APAV: An advanced pangenome analysis and visualization toolkit.PLoS computational biology · 2025Article
- Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain.Physiological genomics · 2025Article
- Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain.bioRxiv : the preprint server for biology · 2024Article
- An overview of pim kinase as a target in multiple myeloma.Cancer medicine · 2023Review
- Targeting Echinococcus multilocularis PIM kinase for improving anti-parasitic chemotherapy.PLoS neglected tropical diseases · 2022Article
- Proviral Integration of Moloney Virus-2 (PIM-2) Expression Level as a Prognostic Marker in Patients with Acute Myeloid Leukemia.International journal of general medicine · 2022Article
- Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.World journal of gastroenterology · 2014Review
- Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.Frontiers in oncology · 2014Review
- Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.Cancer science · 2012Article
- Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.Blood · 2011Article
- Frontier of epilepsy research - mTOR signaling pathway.Experimental & molecular medicine · 2011Review
- For better or for worse: the role of Pim oncogenes in tumorigenesis.Nature reviews. Cancer · 2011Review
- Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10.Development (Cambridge, England) · 2011Article
- Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Biochemical pharmacology · 2010Review
- Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats.BMC neuroscience · 2010Article
- Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.The Journal of biological chemistry · 2009Article
- Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression.Journal of cancer research and clinical oncology · 2008Article
- Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.Cancer science · 2007Article
- Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat.Neuroscience · 2006Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmission and short-term plasticity. However, they fail to consolidate enduring LTP even though Pim-2 and Pim-3 are constitutively expressed in the hippocampus and Pim-3 expression is similarly induced by synaptic activity. Thus, expression of Pim-1 is required for LTP. Its level of expression and, consequently, its capacity to phosphorylate target proteins in dendritic and nuclear compartments of stimulated neurons might be a determining factor for the establishment of long-lasting changes in synaptic strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.