ArticleThe EMBO journal1999
Constitutively active Pto induces a Prf-dependent hypersensitive response in the absence of avrPto.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Wheat tandem kinase RWT4 directly binds a fungal effector to activate defense.Nature genetics · 2025Article
- Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation.PLoS pathogens · 2021Article
- The MAPK Kinase Kinase GmMEKK1 Regulates Cell Death and Defense Responses.Plant physiology · 2018Article
- Behind the lines-actions of bacterial type III effector proteins in plant cells.FEMS microbiology reviews · 2016Review
- A Rice Gene Homologous to Arabidopsis AGD2-LIKE DEFENSE1 Participates in Disease Resistance Response against Infection with Magnaporthe oryzae.The plant pathology journal · 2016Article
- Genome-Wide Analysis and Evolution of the Pto-Like Protein Kinase (PLPK) Gene Family in Pepper.PloS one · 2016Article
- The N-terminal domain of the tomato immune protein Prf contains multiple homotypic and Pto kinase interaction sites.The Journal of biological chemistry · 2015Article
- Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1.Plant physiology · 2014Article
- Solanum resistance genes against Phytophthora infestans and their corresponding avirulence genes.Molecular plant pathology · 2013Review
- TALE1 from Xanthomonas axonopodis pv. manihotis acts as a transcriptional activator in plant cells and is important for pathogenicity in cassava plants.Molecular plant pathology · 2013Article
- The tomato Prf complex is a molecular trap for bacterial effectors based on Pto transphosphorylation.PLoS pathogens · 2013Article
- Activation of a plant nucleotide binding-leucine rich repeat disease resistance protein by a modified self protein.Cellular microbiology · 2012Article
- Rhizobial and fungal symbioses show different requirements for calmodulin binding to calcium calmodulin-dependent protein kinase in Lotus japonicus.The Plant cell · 2012Article
- A tomato LysM receptor-like kinase promotes immunity and its kinase activity is inhibited by AvrPtoB.The Plant journal : for cell and molecular biology · 2012Article
- NLR functions in plant and animal immune systems: so far and yet so close.Nature immunology · 2011Review
- Biochemical and genetic requirements for function of the immune response regulator BOTRYTIS-INDUCED KINASE1 in plant growth, ethylene signaling, and PAMP-triggered immunity in Arabidopsis.The Plant cell · 2011Article
- Dynamic evolution of pathogenicity revealed by sequencing and comparative genomics of 19 Pseudomonas syringae isolates.PLoS pathogens · 2011Article
- Proteolysis of a negative regulator of innate immunity is dependent on resistance genes in tomato and Nicotiana benthamiana and induced by multiple bacterial effectors.The Plant cell · 2009Article
- Crystal structure of the complex between Pseudomonas effector AvrPtoB and the tomato Pto kinase reveals both a shared and a unique interface compared with AvrPto-Pto.The Plant cell · 2009Article
- Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Resistance in tomato to Pseudomonas syringae pv tomato (avrPto) is conferred by the gene Pto in a gene-for-gene relationship. A hypersensitive disease resistance response (HR) is elicited when Pto and avrPto are expressed experimentally within the same plant cell. The kinase capability of Pto was required for AvrPto-dependent HR induction. Systematic mutagenesis of the activation segment of Pto kinase confirmed the homologous P+1 loop as an AvrPto-binding determinant. Specific amino acid substitutions in this region led to constitutive induction of HR upon expression in the plant cell in the absence of AvrPto. Constitutively active Pto mutants required kinase capability for activity, and were unable to interact with proteins previously shown to bind to wild-type Pto. The constitutive gain-of-function phenotype was dependent on a functional Prf gene, demonstrating activation of the cognate disease resistance pathway and precluding a role for Prf upstream of Pto.
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