ArticleThe EMBO journal1999
The mechanism mediating regenerative intercellular Ca2+ waves in the blowfly salivary gland.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 56 citations in OpenAlex.
- Calcium Wave Propagation Underlying Intercellular Signaling and Coordination of Tissue Responses.Function (Oxford, England) · 2022Article
- Spontaneous long-range calcium waves in developing butterfly wings.BMC developmental biology · 2015Article
- Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation.Journal of inflammation (London, England) · 2015Review
- Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an "acupuncture-responding channel".BMC complementary and alternative medicine · 2014Article
- Calcium signaling mediates cold sensing in insect tissues.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans.Development (Cambridge, England) · 2012Article
- Modelling the effects of calcium waves and oscillations on saliva secretion.Journal of theoretical biology · 2012Article
- Special features of mitochondrial Ca²⁺ signalling in adrenal glomerulosa cells.Pflugers Archiv : European journal of physiology · 2012Review
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- Article
- cAMP potentiates InsP3-induced Ca2+ release from the endoplasmic reticulum in blowfly salivary glands.BMC physiology · 2008Article
- Innexins form two types of channels.FEBS letters · 2007Article
- Intercellular calcium signalling in cultured renal epithelia: a theoretical study of synchronization mode and pacemaker activity.European biophysics journal : EBJ · 2004Article
- Intercellular Ca2+ wave propagation through gap-junctional Ca2+ diffusion: a theoretical study.Biophysical journal · 2001Article
- Control of InsP3-induced Ca2+ oscillations in permeabilized blowfly salivary gland cells: contribution of mitochondria.The Journal of physiology · 2000Article
- Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26.Molecular biology of the cell · 2000Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Intercellular Ca2+ signaling in intact salivary glands of the blowfly Calliphora erythrocephala was studied by fluorimetric digital imaging combined with microinjection of putative messenger molecules. Iontophoretic injection of D-myo-inositol 1,4, 5-trisphosphate (InsP3) into salivary gland cells evoked regenerative intercellular Ca2+ waves that spread through the impaled cell and several rows of surrounding cells. Ca2+ increases induced by microinjection of Ca2+ ions were confined to the injected cells and their nearest neighbors. Depletion of intracellular Ca2+ stores by thapsigargin pre-treatment did not alter the time course of the Ca2+ increase caused by Ca2+ injection. However, activation of Ca2+ release became clearly evident when Ca2+ was injected in the presence of serotonin (5-HT). Under these conditions, injection of Ca2+ triggered intercellular Ca2+ waves that consecutively passed through >10 cells. The phospholipase C inhibitor U73122 blocked 5-HT-induced Ca2+ increases but did not affect InsP3-dependent Ca2+ spiking and intercellular Ca2+ wave propagation. The results demonstrate that propagation of agonist-evoked Ca2+ waves in the blowfly salivary gland requires supra-basal [InsP3] but does not depend on feedback activation of phospholipase C. We conclude that the intra- and intercellular transmission of these Ca2+ waves is mediated by diffusion of Ca2+ and Ca2+-induced Ca2+ release via the InsP3 receptor channel.
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