Evidence map›Paper›PMID 10368161›Full record

ArticleJournal of bacteriology1999

Role for the oxyS gene in regulation of intracellular hydrogen peroxide in Escherichia coli.

B González-Flecha, B Demple

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  4. Article
  5. A Peroxide-Responding sRNA Evolved from a Peroxidase mRNA.Molecular biology and evolution · 2022
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

B González-FlechaPhysiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA. bgonzale@hsph.harvard.edu
B Demple
Environmental Health · GBHarvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
OXIDATIVE STRESS--CELLULAR RESPONSES AND GENE CONTROLR01CA037831 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI DEMPLE, BRUCE F. · 1986 to 2004
$1.7M
NCI NIH HHS CA37831NCI NIH HHS R01 CA037831NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES00002
6 · The paper itself

Abstract

Intracellular hydrogen peroxide is regulated in Escherichia coli by OxyR in response to the metabolic production of H2O2. Here, we show that the untranslated oxyS RNA controlled by OxyR has a role in this regulation. The oxyS transcript appears to affect the metabolic output of H2O2 rather than the removal of H2O2 by catalases-hydroperoxidases.

Indexed as

DNA-Binding ProteinsGene Expression Regulation, BacterialBacterial ProteinsEscherichia coliEscherichia coli ProteinsGenes, BacterialGenotypeHydrogen PeroxideOxidative StressRepressor ProteinsRNA, BacterialTranscription FactorsTranscription, GeneticBacterial ProteinsDNA-Binding ProteinsEscherichia coli ProteinsHydrogen PeroxideoxyR protein, E coliRepressor ProteinsRNA, BacterialTranscription Factors

Identifiers

PMID10368161
PMCPMC93864
OpenAlexW2102748671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.