ReviewMedical & biological engineering & computing1998
Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: clinical and fundamental applications.
Review in Medical & biological engineering & computing, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Innovative theranostic hydrogels for targeted gastrointestinal cancer treatment.Journal of translational medicine · 2024Review
- Polymeric DNA Hydrogels and Their Applications in Drug Delivery for Cancer Therapy.Gels (Basel, Switzerland) · 2023Review
- Tissue Engineering in Gynecology.International journal of molecular sciences · 2022Review
- The effect of fibroblast growth factor 7 on human dental pulp stem cells for differentiation to AQP5-positive and αSMA-positive cells in vitro and in vivo.Clinical and experimental dental research · 2021Article
- 3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Isolation and Characterization of a Human Fetal Mesenchymal Stem Cell Population: Exploring the Potential for Cell Banking in Wound Healing Therapies.Cell transplantation · 2019Article
- Effects of incorporation of granule-lyophilised platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing.Scientific reports · 2018Article
- Compression-induced structural and mechanical changes of fibrin-collagen composites.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- The effect of basic fibroblast growth factor on regeneration in a surgical wound model of rat submandibular glands.International journal of oral science · 2016Article
- An Optimized Approach to Recover Secreted Proteins from Fibroblast Conditioned-Media for Secretomic Analysis.Frontiers in cellular neuroscience · 2016Article
- Plucked human hair shafts and biomolecular medical research.TheScientificWorldJournal · 2013Review
- Optimizing in vitro culture conditions leads to a significantly shorter production time of human dermo-epidermal skin substitutes.Pediatric surgery international · 2013Article
- in vitro Decellularization of Rabbit Lung Tissue.Cell journal · 2013Article
- Antibacterial and cell-adhesive polypeptide and poly(ethylene glycol) hydrogel as a potential scaffold for wound healing.Acta biomaterialia · 2012Article
- Biomaterial selection for tooth regeneration.Tissue engineering. Part B, Reviews · 2011Review
- Tissue engineering approaches for the construction of a completely autologous tendon substitute.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2008Article
- Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy.Biophysical journal · 2007Article
- Microvascular engineering in perfusion culture: immunohistochemistry and CLSM findings.Head & face medicine · 2006Article
- Model for human skin reconstructed in vitro composed of associated dermis and epidermis.Sao Paulo medical journal = Revista paulista de medicina · 2006Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of tissue engineering has opened several avenues in biomedical sciences, through ongoing progress. Skin substitutes are currently optimised for clinical as well as fundamental applications. The paper reviews the development of collagen-populated hydrated gels for their eventual use as a therapeutic option for the treatment of burn patients or chronic wounds: tools for pharmacological and toxicological studies, and cutaneous models for in vitro studies. These skin substitutes are produced by culturing keratinocytes on a matured dermal equivalent composed of fibroblasts included in a collagen gel. New biotechnological approaches have been developed to prevent contraction (anchoring devices) and promote epithelial cell differentiation. The impact of dermo-epidermal interactions on the differentiation and organisation of bio-engineered skin tissues has been demonstrated with human skin cells. Human skin substitutes have been adapted for percutaneous absorption studies and toxicity assessment. The evolution of these human skin substitutes has been monitored in vivo in preclinical studies showing promising results. These substitutes could also serve as in vitro models for better understanding of the immunological response and healing mechanism in human skin. Thus, such human skin substitutes present various advantages and are leading to the development of other bio-engineered tissues, such as blood vessels, ligaments and bronchi.
Indexed as
Identifiers
10367474What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.