ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Activity-dependent modulation of rod photoreceptor cyclic nucleotide-gated channels mediated by phosphorylation of a specific tyrosine residue.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides.The Journal of biological chemistry · 2014Trial
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- Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.The Journal of biological chemistry · 2016Article
- Adaptive potentiation in rod photoreceptors after light exposure.The Journal of general physiology · 2014Article
- Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.The Journal of general physiology · 2013Article
- Insulin receptor regulates photoreceptor CNG channel activity.American journal of physiology. Endocrinology and metabolism · 2012Article
- Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.Biochimica et biophysica acta · 2009Article
- Circadian regulation of ion channels and their functions.Journal of neurochemistry · 2009Review
- Regulation of ON bipolar cell activity.Progress in retinal and eye research · 2008Review
- Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Tyrosine phosphorylation of cGMP-gated ion channels is under circadian control in chick retina photoreceptors.Investigative ophthalmology & visual science · 2007Article
- Defining the retinoid binding site in the rod cyclic nucleotide-gated channel.The Journal of general physiology · 2005Article
- All-trans-retinal is a closed-state inhibitor of rod cyclic nucleotide-gated ion channels.The Journal of general physiology · 2004Article
- Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels.The Journal of physiology · 2003Article
- A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore.The Journal of general physiology · 2003Article
- Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Influence of permeant ions on gating in cyclic nucleotide-gated channels.The Journal of general physiology · 2003Article
- Regulation of structural plasticity by different channel types in rod and cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Potentiation of 'on' bipolar cell flash responses by dim background light and cGMP in dogfish retinal slices.The Journal of physiology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cyclic nucleotide-gated (CNG) channels are crucial for phototransduction in vertebrate rod photoreceptors. The cGMP sensitivity of these channels is modulated by diffusible intracellular messengers, including Ca2+/calmodulin, contributing to negative feedback during sensory adaptation. Membrane-associated protein tyrosine kinases and phosphatases also modulate rod CNG channels, but whether this results from direct changes in the phosphorylation state of the channel protein has been unclear. Here, we show that bovine rod CNG channel alpha-subunits (bRET) contain a tyrosine phosphorylation site crucial for modulation. bRET channels expressed in Xenopus oocytes exhibit modulation, whereas rat olfactory CNG channels (rOLF) do not. Chimeric channels reveal that differences in the C terminus, containing the cyclic nucleotide-binding domain, account for this difference. One specific tyrosine in bRET (Y498) appears to be crucial; replacement of this tyrosine in bRET curtails modulation, whereas installation into rOLF confers modulability. As the channel becomes dephosphorylated, there is an increase in the rate of spontaneous openings in the absence of ligand, indicating that changes in the phosphorylation state affect the allosteric gating equilibrium. Moreover, we find that dephosphorylation, which favors channel opening, requires open channels, whereas phosphorylation, which promotes channel closing, requires closed channels. Hence, modulation by changes in tyrosine phosphorylation is activity-dependent and may constitute a positive feedback mechanism, contrasting with negative feedback systems underlying adaptation.
Indexed as
Identifiers
10366613PMC6782659W1496131947What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.