ArticleAmerican journal of human genetics1999
Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Osteoarthritis susceptibility loci defined by genome scan meta-analysis.Rheumatology international · 2006Pooled it
- Osteoarthritis susceptibility loci defined by genome scan meta-analysis.Rheumatology international · 2006Pooled it
- Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.Journal of Cancer · 2016Article
- LRP receptor family member associated bone disease.Reviews in endocrine & metabolic disorders · 2015Review
- Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?Expert review of neurotherapeutics · 2012Review
- Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.Arthritis and rheumatism · 2010Article
- Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.Genes and immunity · 2008Article
- Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.Osteoarthritis and cartilage · 2008Article
- [Pathogenesis of osteoarthritis--a snapshot].Zeitschrift fur Rheumatologie · 2007Review
- Osteoarthritis linkage scan: more loci for the geneticists to investigate.Annals of the rheumatic diseases · 2006Article
- Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.The Biochemical journal · 2006Article
- Linkage to nodal osteoarthritis: quantitative and qualitative analyses of data from a whole-genome screen identify trait-dependent susceptibility loci.Annals of the rheumatic diseases · 2006Article
- Familial osteoarthritis of the hip joint associated with acetabular dysplasia maps to chromosome 13q.American journal of human genetics · 2006Article
- Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families.Arthritis research & therapy · 2006Article
- Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study.Annals of the rheumatic diseases · 2004Article
- Genetics of osteoarthritis.Current rheumatology reports · 2004Review
- Osteoarthritis: understanding the pathophysiology, genetics, and treatments.Journal of the National Medical Association · 2003Review
- Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3.American journal of human genetics · 2003Article
- The role of structural genes in the pathogenesis of osteoarthritic disorders.Arthritis research · 2002Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P</=.05 were then taken through to the second stage, with an additional 184 families. This second stage confirmed evidence of linkage for markers on chromosome 11q. Additional markers from this region were then typed to create a denser map. We obtained a maximum single-point LOD score, at D11S901, of 2.40 (P=.0004) and a maximum multipoint-LOD score of 3.15, between markers D11S1358 and D11S35. A subset of 196 of the 481 families, comprising affected female sibling pairs, generated a corrected LOD score of 2.54 (P=.0003) for marker D11S901, with evidence for linkage extending 12 cM proximal to this marker. When we stratified for affected male sibling pairs there was no evidence of linkage to chromosome 11. Our data suggest that a female-specific susceptibility gene for idiopathic osteoarthritis is located on chromosome 11q.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.