ArticleJournal of virology1999
Expression and use of human immunodeficiency virus type 1 coreceptors by human alveolar macrophages.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Brain Microglial Cells Are Highly Susceptible to HIV-1 Infection and Spread.AIDS research and human retroviruses · 2017Article
- The complexity of HIV persistence and pathogenesis in the lung under antiretroviral therapy: challenges beyond AIDS.Viral immunology · 2014Review
- Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates.BMC immunology · 2012Article
- Adenovirus vectors block human immunodeficiency virus-1 replication in human alveolar macrophages by inhibition of the long terminal repeat.American journal of respiratory cell and molecular biology · 2010Article
- Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon production.AIDS research and human retroviruses · 2010Article
- HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Antiretroviral therapy in macrophages: implication for HIV eradication.Antiviral chemistry & chemotherapy · 2009Review
- Human immunodeficiency virus infection alters tumor necrosis factor alpha production via Toll-like receptor-dependent pathways in alveolar macrophages and U1 cells.Journal of virology · 2008Article
- Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1.Journal of virology · 2008Article
- Leishmania infection impairs beta 1-integrin function and chemokine receptor expression in mononuclear phagocytes.Infection and immunity · 2006Article
- Impairment of beta chemokine and cytokine production in patients with HIV related Pneumocystis jerovici pneumonia.Thorax · 2004Article
- Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophages.Journal of virology · 2003Article
- CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection.The Journal of experimental medicine · 2003Article
- Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating variants that are macrophage tropic.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages.International journal of hematology · 2002Review
- Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Human immunodeficiency virus type 1 (HIV-1) requires, in addition to CD4, coreceptors of the CC or CXC chemokine families for productive infection of T cells and cells of the monocyte-macrophage lineage. Based on the hypothesis that coreceptor expression on alveolar macrophages (AM) may influence HIV-1 infection of AM in the lung, this study analyzes the expression and utilization of HIV-1 coreceptors on AM of healthy individuals. AM were productively infected with five different primary isolates of HIV-1. Levels of surface expression of CCR5, CXCR4, and CD4 were low compared to those of blood monocytes, but CCR3 was not detectable. mRNA for CCR5, CXCR4, CCR2, and CCR3 were all detectable, but to varying degrees and with variability among donors. Expression of CCR5, CXCR4, and CCR2 mRNA was downregulated following stimulation with lipopolysaccharide (LPS). In contrast, secretion of the chemokines RANTES, MIP-1alpha, and MIP-1beta was upregulated with LPS stimulation. Interestingly, HIV-1 replication was diminished following LPS stimulation. Infection of AM with HIV-1 in the presence of the CC chemokines demonstrated blocking of infection. Together, these studies demonstrate that AM can be infected by a variety of primary HIV-1 isolates, AM express a variety of chemokine receptors, the dominant coreceptor used for HIV entry into AM is CCR5, the expression of these receptors is dependent on the state of activation of AM, and the ability of HIV-1 to infect AM may be modulated by expression of the chemokine receptors and by chemokines per se.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.