ArticleJournal of virology1999
Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses.Journal of virology · 2025Article
- Impact of human immunodeficiency virus on pulmonary vascular disease.Global cardiology science & practice · 2021Review
- Visualization and quantification of simian immunodeficiency virus-infected cells using non-invasive molecular imaging.The Journal of general virology · 2015Article
- Macaques as model hosts for studies of HIV-1 infection.Frontiers in microbiology · 2013Article
- Article
- Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1.Journal of virology · 2011Article
- Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques.AIDS research and human retroviruses · 2011Article
- Nef proteins from simian immunodeficiency viruses are tetherin antagonists.Cell host & microbe · 2009Article
- Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?Nature reviews. Microbiology · 2009Review
- Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.PLoS pathogens · 2009Article
- HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.American journal of respiratory and critical care medicine · 2006Article
- Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.Journal of virology · 2005Article
- Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo.Journal of virology · 2005Article
- Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus.Journal of virology · 2004Article
- Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.Journal of virology · 2004Article
- Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1.Journal of virology · 2004Article
- Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.Journal of virology · 2004Article
- Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.Journal of virology · 2003Article
- A dominant block to HIV-1 replication at reverse transcription in simian cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A nef gene is present in all primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus of macaque monkeys (SIVmac). However, the nef genes of HIV-1 and SIVmac exhibit minimal sequence identity, and not all properties are shared by the two. Nef sequences of SIVmac239 were replaced by four independent nef alleles of HIV-1 in a context that was optimal for expression. The sources of the HIV-1 nef sequences included NL 4-3, a variant NL 4-3 gene derived from a recombinant-infected rhesus monkey, a patient nef allele, and a nef consensus sequence. Of 16 rhesus monkeys infected with these SHIVnef chimeras, 9 maintained high viral loads for prolonged periods, as observed with the parental SIVmac239, and 6 have died with AIDS 52 to 110 weeks postinfection. Persistent high loads were observed at similar frequencies with the four different SIV recombinants that expressed these independent HIV-1 nef alleles. Infection with other recombinant SHIVnef constructions resulted in sequence changes in infected monkeys that either created an open nef reading frame or optimized the HIV-1 nef translational context. The HIV-1 nef gene was uniformly retained in all SHIVnef-infected monkeys. These results demonstrate that HIV-1 nef can substitute for SIVmac nef in vivo to produce a pathogenic infection. However, the model suffers from an inability to consistently obtain persisting high viral loads in 100% of the infected animals, as is observed with the parental SIVmac239.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.