ArticleGenes & development1999
Cell cycle-regulated histone acetylation required for expression of the yeast HO gene.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 276 citations in OpenAlex.
- A two-step regulatory mechanism dynamically controls histone H3 acetylation by SAGA complex at growth-related promoters.Nucleic acids research · 2025Article
- Article
- Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies.Scientific reports · 2021Article
- Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation.Nature metabolism · 2021Article
- Mechanisms of stimulation of SAGA-mediated nucleosome acetylation by a transcriptional activator.Biochemistry and biophysics reports · 2021Article
- Evolution of Regulated Transcription.Cells · 2020Review
- Article
- Chromatin remodelers: We are the drivers!!Nucleus (Austin, Tex.) · 2016Review
- Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders.Frontiers in behavioral neuroscience · 2015Review
- Chromatin dynamics: interplay between remodeling enzymes and histone modifications.Biochimica et biophysica acta · 2014Review
- Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S.Molecular cell · 2013Article
- Creating memories of transcription.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Stochastic expression and epigenetic memory at the yeast HO promoter.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Chromatin and transcription in yeast.Genetics · 2012Review
- Review
- Histone dynamics and roles of histone acetyltransferases during cold-induced gene regulation in Arabidopsis.Plant molecular biology · 2010Article
- Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle.Developmental cell · 2010Article
- Article
- Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast.PLoS biology · 2009Article
- SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter.Molecular and cellular biology · 2009Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the yeast HO gene in late G1 of the cell cycle requires the SWI/SNF chromatin remodeling complex, the Gcn5p histone acetyltransferase, and two different sequence-specific transcriptional activators, Swi5p and Swi4p/Swi6p. We have used chromatin immunoprecipitation assays to investigate the role of each of these trans-acting factors in establishing a cell cycle-regulated domain of histone acetylation surrounding the HO upstream regulatory region. We detect a approximately 1-kb domain of H3 and H4 acetylation that is established in mid-G1, prior to and independent of HO transcription, which then declines with kinetics similar to inactivation of HO. This cell cycle burst of histone acetylation requires Gcn5p, SWI/SNF, and the Swi5p activator, but occurs in the absence of the Swi4p activator. We also find that inactivation of the Sin3p/Rpd3p deacetylase complex leads to a high level of acetylation at the HO locus throughout the cell cycle. We propose a sequential model for activation of HO in which the Swi5p-dependent recruitment of the Gcn5p acetyltransferase requires chromatin remodeling events by the SWI/SNF complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.