Trial reportAnnals of surgery1999
Patterns of nodal metastases in palpable medullary thyroid carcinoma: recommendations for extent of node dissection.
Trial report in Annals of surgery, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01838642 (A Phase II Study of Ponatinib in Advanced or Metastatic Medullary Thyroid Cancer), which is not on this map. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II Study of Ponatinib in Advanced or Metastatic Medullary Thyroid Cancer
Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 402 citations in OpenAlex.
- Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.Thyroid : official journal of the American Thyroid Association · 2015Guideline
- Guideline
- Is intraoperative calcitonin monitoring useful to modulate the extension of neck dissection in patients with medullary thyroid carcinoma?World journal of surgery · 2014Trial
- Beyond Tumor Diameter: Exploratory Cohort-Derived Calcitonin Secretory Categories and Invasive Pathology in Medullary Thyroid Carcinoma.Current oncology (Toronto, Ont.) · 2026Article
- The Management of Medullary Thyroid Cancer: A Review.Annals of surgical oncology · 2026Review
- Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma.Nature communications · 2026Article
- Tailored Surgery for Medullary Thyroid Cancer (MTC) Based on Pretherapeutic Basal Calcitonin and Intraoperative Diagnosis of Desmoplastic Stroma Reaction: A Proposal for a New Surgical Concept.Annals of surgical oncology · 2025Article
- The value ofCancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Surgical Treatment of Medullary Thyroid Cancer.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Epidemiology, Clinical Presentation, and Diagnosis of Medullary Thyroid Carcinoma.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Distinct Impacts of Clinicopathological and Mutational Profiles on Long-Term Survival and Recurrence in Medullary Thyroid Carcinoma.Endocrinology and metabolism (Seoul, Korea) · 2024Article
- Article
- Article
- Article
- Thyroidectomy without lymph node dissection should be considered for stage T1 medullary thyroid carcinoma: a population-based cohort study.Frontiers in endocrinology · 2024Article
- Management of Medullary Thyroid Cancer: Patterns of Recurrence and Outcomes of Reoperative Surgery.The oncologist · 2023Article
- Sentinel node mapping in thyroid cancer: an overview.Frontiers in medicine · 2023Article
- Preservation of parathyroid glands during thyroid and neck surgery.Frontiers in endocrinology · 2023Review
- Management of lymph nodes in medullary thyroid carcinoma: A review.Annals of medicine and surgery (2012) · 2022Review
- Management of medullary carcinoma of the thyroid: a review.The Journal of international medical research · 2022Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo establish the frequency, pattern and location of cervical lymph node metastases from palpable medullary thyroid carcinoma (MTC). Recommendations are made regarding the extent of surgery for this tumor. SUMMARY BACKGROUND DATA: Medullary thyroid carcinoma is a tumor of neuroendocrine origin that does not concentrate iodine. Surgical extirpation of the thyroid tumor and cervical node metastases is the only potentially curative therapeutic option. Patterns of node metastases in the neck and guidelines for the extent of dissection for palpable MTC are not well established.
methodsSeventy-three patients underwent thyroidectomy for palpable MTC with immediate or delayed central and bilateral functional neck dissections. The number and location of lymph node metastases in the central (levels VI and VII) and bilateral (levels II to V) nodal groups were noted and were correlated with the size and location of the primary thyroid tumor. Intraoperative assessment of nodal status by palpation and inspection by the surgeon was correlated with results of histologic examination.
resultsPatients with unilateral intrathyroid tumors had lymph node metastases in 81% of central node dissections, 81% of ipsilateral functional (levels II to V) dissections, and 44% of contralateral functional (levels II to V) dissections. In patients with bilateral intrathyroid tumors, nodal metastases were present in 78% of central node dissections, 71% of functional (levels II to V) node dissections ipsilateral to the largest intrathyroid tumor, and 49% of functional (levels II to V) node dissections contralateral to the largest thyroid tumor. The sensitivity of the surgeon's intraoperative assessment for nodal metastases was 64%, and the specificity was 71%.
conclusionIn this series, >75% of patients with palpable MTC had associated nodal metastases, which often were not apparent to the surgeon. Routine central and bilateral functional neck dissections should be considered in all patients with palpable MTC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.