ArticleMolecular biology reports1999
Changes in 20S proteasome activity during ageing of the LOU rat.
Article in Molecular biology reports, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pooled it
- Article
- Altered Proteasome Composition in Aging Brains, Genetic Proteasome Augmentation Mitigates Age-Related Cognitive Declines, and Acute Proteasome Agonist Treatment Rescues Age-Related Cognitive Deficits in Mice.bioRxiv : the preprint server for biology · 2024Article
- Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease.Frontiers in cell and developmental biology · 2023Review
- Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation.Frontiers in molecular biosciences · 2021Review
- Docosahexaenoic Acid, a Potential Treatment for Sarcopenia, Modulates the Ubiquitin-Proteasome and the Autophagy-Lysosome Systems.Nutrients · 2020Review
- Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy.Frontiers in cell and developmental biology · 2020Article
- Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity.The Journal of biological chemistry · 2018Article
- Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.Current genomics · 2014Article
- Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.The Journal of biological chemistry · 2010Article
- Supplementation of deprenyl attenuates age associated alterations in rat cerebellum.Molecular biology reports · 2010Article
- Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training.Journal of cachexia, sarcopenia and muscle · 2010Article
- Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Understanding proteasome assembly and regulation: importance to cardiovascular medicine.Trends in cardiovascular medicine · 2008Review
- Role of proteasomes in disease.BMC biochemistry · 2007Review
- Redox regulation of the proteasome in T lymphocytes during aging.Free radical biology & medicine · 2007Article
- A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle.The Journal of physiology · 2005Article
- Effect of age on skeletal muscle proteolysis in extensor digitorum longus muscles of B6C3F1 mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscular functions decline and muscle mass decreases during ageing. In the rat, there is a 27% decrease in muscle protein between 18 and 34 months of age. We examined age-related changes in the proteasome-dependent proteolytic pathway in rats at 4, 18, 24, 29 and 34 months of age. The three best characterised activities of the proteasome (chymotrypsin-like, trypsin-like and peptidylglutamyl peptide hydrolase) increased to 29 months and then decreased in the senescent animal. These variations in activity were accompanied by an identical change in the quantity of 20S proteasome measured by Western blot, whereas the S4 subunit of the 19S regulator and the quantity of ubiquitin-linked proteins remained constant. mRNA of subunits C3, C5, C9, and S4 increased in the senescent animal, but ubiquitin mRNA levels were unchanged. These findings suggest that the 20S proteasome may be partly responsible for the muscular atrophy observed during ageing in the rat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.