ArticleThe American journal of pathology1999
Histological damage in chronic hepatitis C is not related to the extent of infection in the liver.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 59 citations in OpenAlex.
- Quantification of hepatic FOXP3+ T-lymphocytes in HIV/hepatitis C coinfection.Journal of viral hepatitis · 2014Article
- Detection of hepatitis C virus (HCV) negative strand RNA and NS3 protein in peripheral blood mononuclear cells (PBMC): CD3+, CD14+ and CD19+.Virology journal · 2013Article
- Chronic hepatitis C.Gut and liver · 2011Article
- A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease.Gastroenterology · 2009Article
- Molecular and bioinformatic evidence of hepatitis C virus evolution in brain.The Journal of infectious diseases · 2008Article
- Ultracentrifugation of serum samples allows detection of hepatitis C virus RNA in patients with occult hepatitis C.Journal of virology · 2007Article
- Intrahepatic hepatitis C virus replication correlates with chronic hepatitis C disease severity in vivo.Journal of virology · 2006Article
- Percentage of hepatitis C virus-infected hepatocytes is a better predictor of response than serum viremia levels.The Journal of molecular diagnostics : JMD · 2005Article
- Transglutaminase type II plays a protective role in hepatic injury.The American journal of pathology · 2003Article
- Comparison of serum hepatitis C virus RNA and core antigen concentrations and determination of whether levels are associated with liver histology or affected by specimen storage time.Journal of clinical microbiology · 2002Article
- Intracellular cytokine analysis of CD4-positive T cells predictive of sustained response to interferon therapy for patients with chronic hepatitis C.Digestive diseases and sciences · 2002Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has not been completely elucidated whether the liver injury induced by the hepatitis C virus (HCV) is due to direct cytopathic damage or to an immune-mediated response against HCV-infected hepatocytes. In this work, we have determined the percentage of HCV-infected hepatocytes, the histological activity index, and the viremia levels in chronically HCV-infected patients with different grades of liver injury to investigate any possible correlation between them. For that purpose, liver biopsies from 27 patients with HCV chronic hepatitis were analyzed by in situ hybridization. This technique revealed that the percentage of infected hepatocytes ranged from 0.04% to 83.6%. Regarding the viremia levels, HCV RNA concentration ranged from 1.8 x 10(3) to 1.4 x 10(6) genome copies/ml. A significant correlation (r = 0.54; P = 0.003) between the percentage of infected hepatocytes and the viremia levels was found. In contrast, no correlation was observed between the percentage of HCV-infected hepatocytes or the viremia levels and the histological activity index. In conclusion, we have shown that the HCV viremia reflects the extent of the infection in the liver and that the liver injury in chronic HCV infection is not directly related to either the number of infected hepatocytes or the serum HCV RNA concentration.
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