ArticleThe American journal of pathology1999
Colorectal adenoma and cancer divergence. Evidence of multilineage progression.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Quantifying cell divisions along evolutionary lineages in cancer.Nature genetics · 2025Article
- The evolutionary theory of cancer: challenges and potential solutions.Nature reviews. Cancer · 2024Review
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- Quantification of subclonal selection in cancer from bulk sequencing data.Nature genetics · 2018Article
- The evolution of tumour phylogenetics: principles and practice.Nature reviews. Genetics · 2017Review
- Immunohistochemical assessment of mitochondrial superoxide dismutase (MnSOD) in colorectal premalignant and malignant lesions.Przeglad gastroenterologiczny · 2016Article
- Spatial invasion dynamics on random and unstructured meshes: implications for heterogeneous tumor populations.Journal of theoretical biology · 2014Article
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- Unraveling intestinal stem cell behavior with models of crypt dynamics.Integrative biology : quantitative biosciences from nano to macro · 2014Review
- Single-cell sequencing-based technologies will revolutionize whole-organism science.Nature reviews. Genetics · 2013Review
- A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution.Biology open · 2013Article
- Comparing algorithms that reconstruct cell lineage trees utilizing information on microsatellite mutations.PLoS computational biology · 2013Article
- Intra-tumour heterogeneity: a looking glass for cancer?Nature reviews. Cancer · 2012Review
- Clonal evolution in cancer.Nature · 2012Review
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- The role of genetic diversity in cancer.The Journal of clinical investigation · 2010Article
- Mammary carcinoma behavior is programmed in the precancer stem cell.Breast cancer research : BCR · 2008Article
- Cancer as an evolutionary and ecological process.Nature reviews. Cancer · 2006Review
- Crypt dynamics and colorectal cancer: advances in mathematical modelling.Cell proliferation · 2006Article
- Genomic variability within an organism exposes its cell lineage tree.PLoS computational biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Colorectal cancer progression involves changes in phenotype and genotype. Although usually illustrated as a linear process, more complex underlying pathways have not been excluded. The object of this paper is to apply modern quantitative principles of molecular evolution to multistep tumor progression. To reconstruct progression lineages, the genotypes of two adjacent adenoma-cancer pairs were determined by serial dilution and polymerase chain reaction at 28-30 microsatellite (MS) loci and then traced back to their most recent common ancestor. The tumors were mismatch repair deficient, and therefore relatively large numbers of MS mutations should accumulate during progression. As expected, the MS genotypes were similar (correlation coefficients >0.9) between different parts of the same adenoma or cancer, but very different (correlation coefficients <0. 2) between unrelated metachronous adenoma-cancer pairs. Unexpectedly, the genotypes of the adjacent adenoma-cancer pairs were also very different (correlation coefficients of 0.30 and 0.36), consistent with early adenoma-cancer divergence rather than direct linear progression. More than 60% of the divisions occurred after this early adenoma-cancer divergence. Therefore, the tumor phylogenies were not consistent with sequential stepwise selection along a single most "fit" and frequent lineage from adenoma to cancer. Instead, one effective early progression strategy creates and maintains multiple evolving candidate lineages, which are subsequently selected for terminal clonal expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.