ArticleThe American journal of pathology1999
Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 133 citations in OpenAlex.
- B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin.Arthritis research & therapy · 2012Trial
- Integrated Mendelian Randomization and Single-Cell RNA Sequencing Analyses Reveal Lactate Metabolism as a Key Pathway in COVID-19-Induced Pulmonary Fibrosis.Canadian respiratory journal · 2026Article
- Review
- Syndrome of Combined Pulmonary Fibrosis and Emphysema: An Official ATS/ERS/JRS/ALAT Research Statement.American journal of respiratory and critical care medicine · 2022Article
- Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-AssociatedChildren (Basel, Switzerland) · 2021Article
- Animal models of emphysema.Chinese medical journal · 2019Review
- Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2019Article
- Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review.International journal of molecular sciences · 2019Review
- Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort.ERJ open research · 2019Article
- RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.Respiratory research · 2017Article
- p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Review
- A network model of correlated growth of tissue stiffening in pulmonary fibrosis.New journal of physics · 2014Article
- The impact of emphysema in pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Combined pulmonary fibrosis and emphysema in a tyre industry worker.Lung India : official organ of Indian Chest Society · 2012Article
- Combined Pulmonary Fibrosis and Emphysema Syndrome: A New Phenotype within the Spectrum of Smoking-Related Interstitial Lung Disease.Pulmonary medicine · 2012Article
- Mesenchymal cell survival in airway and interstitial pulmonary fibrosis.Fibrogenesis & tissue repair · 2010Article
- Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells.Hepatology research : the official journal of the Japan Society of Hepatology · 2010Article
- Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited.Seminars in immunopathology · 2008Review
- The role of PDGF in radiation oncology.Radiation oncology (London, England) · 2007Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Because of its expression pattern and its potent effects on mesenchymal cells, platelet-derived growth factor (PDGF) has been implicated as an important factor in epithelial-mesenchymal cell interactions during normal lung development and in the pathogenesis of fibrotic lung disease. To further explore the role of PDGF in these processes, we have developed transgenic mice that express the PDGF-B gene from the lung-specific surfactant protein C (SPC) promoter. Adult SPC-PDGFB transgenic mice exhibited lung pathology characterized by enlarged airspaces, inflammation, and fibrosis. Emphysematous changes frequently occurred throughout the lung, but inflammation and fibrotic lesions were usually confined to focal areas. The severity of this phenotype varied significantly among individual mice within the same SPC-PDGFB transgenic lineage. A pathology similar to that observed in adult mice was noted in lungs from transgenic mice as young as 1 week of age. Neonatal transgenic mice exhibited enlarged saccules and thickened primary septa. Results of these studies indicated that overexpression of PDGF-B induced distinct abnormalities in the developing and adult lung and led to a complex phenotype that encompassed aspects of both emphysema and fibrotic lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.