ArticleClinical and experimental immunology1999
Mode of delivery directs the phagocyte functions of infants for the first 6 months of life.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies.Diabetologia · 2008Pooled it
- Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins.International journal of environmental research and public health · 2021Review
- Mode of delivery by an ulcerative colitis mother in a case of twins: Immunological differences in cord blood and placenta.World journal of gastroenterology · 2018Article
- Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study.JAMA pediatrics · 2016Article
- Efficacy of screening immune system function in at-risk newborns.The Australasian medical journal · 2014Review
- Microbial contact during pregnancy, intestinal colonization and human disease.Nature reviews. Gastroenterology & hepatology · 2012Review
- The effect of mode of delivery on T regulatory (Treg) cells of cord blood.Indian journal of pediatrics · 2011Article
- Measurement of complement receptor 1 on neutrophils in bacterial and viral pneumonia.BMC infectious diseases · 2006Article
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Factors that direct the immune responsiveness of the newborn beyond the immediate post-natal period are not known. We investigated the influence of mode of delivery and type of feeding on the phagocyte activity during the first 6 months of life. Sixty-four healthy infants (34 delivered vaginally and 30 by elective Caesarean section) were studied at birth and at the ages of 2 and 6 months. Phagocyte functions were studied by measuring the chemiluminescence (CL) activity of whole blood and isolated leucocytes and by investigating the expression of phagocyte receptors (FcgammaRI (CD64), FcgammaRII (CD32), FcgammaRIII (CD16), CR1 (CD35), CR3 (CD11b) and FcalphaR (CD89)) on neutrophils, monocytes and eosinophils by using receptor-specific MoAbs and immunofluorescence flow cytometry. Infants born by elective Caesarean section had significantly higher CL activity than those delivered vaginally during the entire 6-month follow up. In addition, infants who received formula feeds had significantly higher CL activity at 6 months of age and higher expression of FcgammaRI-, Fcalpha- and CR3-receptors on neutrophils than infants exclusively breast-fed. We suggest that stress reaction associated with labour influences the phagocytic activity measured in the cord blood but later during infancy the intraluminal antigens, gut microflora and diet, become important determinants in immune programming of human individuals.
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