ArticleProceedings of the National Academy of Sciences of the United States of America1999
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 135 citations in OpenAlex.
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- Cord blood-derived biologics lead to robust axonal regeneration in benzalkonium chloride-injured mouse corneas by modulating the Il-17 pathway and neuropeptide Y.Molecular medicine (Cambridge, Mass.) · 2024Article
- SARS-CoV-2 and pathological matrix remodeling mediators.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Review
- Determination of Chemical Irritation Potential Using a Defined Gene Signature Set on Tissue-Engineered Human Skin Equivalents.JID innovations : skin science from molecules to population health · 2021Article
- Assessment of Selected Matrix Metalloproteinases (MMPs) and Correlation with Cytokines in Psoriatic Patients.Mediators of inflammation · 2021Article
- Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.The Yale journal of biology and medicine · 2020Review
- Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis.PloS one · 2020Article
- Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin.International journal of molecular sciences · 2019Article
- Proteases in Pemphigoid Diseases.Frontiers in immunology · 2019Review
- Rational design of antirheumatic prodrugs specific for sites of inflammation.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity.The Journal of experimental medicine · 2015Article
- Selective gelatinase inhibition reduces apoptosis and pro-inflammatory immune cell responses in Campylobacter jejuni-infected gnotobiotic IL-10 deficient mice.European journal of microbiology & immunology · 2014Article
- Article
- The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.Gut pathogens · 2014Article
- Metalloproteinases and their natural inhibitors in inflammation and immunity.Nature reviews. Immunology · 2013Review
- Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica.Infection and immunity · 2013Article
- The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 ameliorates acute DSS colitis.European journal of microbiology & immunology · 2012Article
- Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The distinct roles of MMP-2 and MMP-9 in acute DSS colitis.European journal of microbiology & immunology · 2011Article
- Selective gelatinase blockage ameliorates acute DSS colitis.European journal of microbiology & immunology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Matrix metalloproteinases (MMPs) are expressed by T cells and macrophages, but there is a paucity of evidence for their role in immune responses. We have studied mice with deficiencies of stromelysin-1 (MMP-3) or gelatinase B (MMP-9) in a dinitrofluorobenzene (DNFB)-induced model of contact hypersensitivity (CHS). Stromelysin-1-deficient mice showed a markedly impaired CHS response to topical DNFB, although they responded normally to cutaneously applied phenol, an acute irritant. Lymphocytes from lymph nodes of DNFB-sensitized stromelysin-1-deficient mice did not proliferate in response to specific soluble antigen dinitrobenzenesulfonic acid, but did proliferate identically to lymph node lymphocytes from wild-type mice when presented with the mitogen Con A. An intradermal injection of stromelysin-1 immediately before DNFB sensitization rescued the impaired CHS response to DNFB in stromelysin-1-deficient mice. Unlike stromelysin-1-deficient mice, gelatinase B-deficient mice exhibited a CHS response comparable to wild-type controls at 1 day postchallenge, but the response persisted beyond 7 days in contrast to the complete resolution observed in wild-type mice by 7 days. However, gelatinase B-deficient mice had a normal rate of resolution of acute inflammation elicited by cutaneous phenol. Gelatinase B-deficient mice failed to show IL-10 production at the site of CHS, an essential feature of resolution in control mice. These results indicate that stromelysin-1 and gelatinase B serve important functions in CHS. Stromelysin-1 is required for initiation of the response, whereas gelatinase B plays a critical role in its resolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.