ArticleProceedings of the National Academy of Sciences of the United States of America1999
A novel mechanism for P element homing in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
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- The border between the ultrabithorax and abdominal-A regulatory domains in the Drosophila bithorax complex.Genetics · 2013Article
- Polycomb group response elements in Drosophila and vertebrates.Advances in genetics · 2013Review
- P-element homing is facilitated by engrailed polycomb-group response elements in Drosophila melanogaster.PloS one · 2012Article
- Target site selection by the mariner-like element, Mos1.Genetica · 2010Article
- A chromatin insulator mediates transgene homing and very long-range enhancer-promoter communication.Development (Cambridge, England) · 2009Article
- Enhancer-promoter communication at the Drosophila engrailed locus.Development (Cambridge, England) · 2009Article
- Post-integration behavior of a Minos transposon in the malaria mosquito Anopheles stephensi.Molecular genetics and genomics : MGG · 2007Article
- Site-specific genomic targeting in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Patterns of Hermes transposition in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P element insertion is essentially random at the scale of the genome. However, P elements containing regulatory sequences from Drosophila engrailed and polyhomeotic genes and from the Bithorax and Antennapedia complexes show some insertional specificity by frequently inserting near the parent gene (homing) and/or near genes containing Polycomb group response elements (preferential insertion). This phenomenon is thought to be mediated by Polycomb group proteins. In this report, we describe a case of homing of P elements containing regulatory sequences of the linotte gene. This homing occurs with high frequency (up to 20% of the lines) and high precision (inserted into a region of <1 kilobase). We present evidence showing that it is not mediated by Polycomb group proteins but by a new, as yet unknown, mechanism. We also suggest that P element homing could be a more frequent phenomenon than generally assumed and that it could become a powerful tool of Drosophila reverse genetics, for which there is no other described gene targeting technique.
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