ArticleProceedings of the National Academy of Sciences of the United States of America1999
CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 281 citations in OpenAlex.
- Molecular characteristics of apolipoprotein M and its biological functions in kidney diseases.Molecular and cellular biochemistry · 2026Review
- NR5A2 controls gene expression and chromatin contacts of essential circadian metabolic genes in the liver.Cellular and molecular life sciences : CMLS · 2026Article
- Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling.Lipids in health and disease · 2025Article
- Another One Bites the Gut: Nuclear Receptor LRH-1 in Intestinal Regeneration and Cancer.Cancers · 2021Review
- Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis.Liver research (Beijing, China) · 2020Article
- Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis.Molecular and cellular endocrinology · 2020Review
- Nuclear receptors, cholesterol homeostasis and the immune system.The Journal of steroid biochemistry and molecular biology · 2019Review
- LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis.EBioMedicine · 2019Article
- Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment.Current diabetes reports · 2018Review
- Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis.Journal of clinical and translational research · 2018Article
- LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness.Oncotarget · 2017Article
- Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.Nature reviews. Drug discovery · 2016Review
- Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer.Cancer biology & therapy · 2015Review
- Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells.Drug design, development and therapy · 2015Article
- Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1.PloS one · 2014Article
- The orphan nuclear receptors at their 25-year reunion.Journal of molecular endocrinology · 2013Review
- Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr -/- mice versus hamsters.Journal of lipid research · 2013Article
- Clocks underneath: the role of peripheral clocks in the timing of female reproductive physiology.Frontiers in endocrinology · 2013Article
- Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription.PloS one · 2013Article
- Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.The Journal of biological chemistry · 2012Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesterol 7alpha-hydroxylase is the first and rate-limiting enzyme in a pathway through which cholesterol is metabolized to bile acids. The gene encoding cholesterol 7alpha-hydroxylase, CYP7A, is expressed exclusively in the liver. Overexpression of CYP7A in hamsters results in a reduction of serum cholesterol levels, suggesting that the enzyme plays a central role in cholesterol homeostasis. Here, we report the identification of a hepatic-specific transcription factor that binds to the promoter of the human CYP7A gene. We designate this factor CPF, for CYP7A promoter binding factor. Mutation of the CPF binding site within the CYP7A promoter abolished hepatic-specific expression of the gene in transient transfection assays. A cDNA encoding CPF was cloned and identified as a human homolog of the Drosophila orphan nuclear receptor fushi tarazu F1 (Ftz-F1). Cotransfection of a CPF expression plasmid and a CYP7A reporter gene resulted in specific induction of CYP7A-directed transcription. These observations suggest that CPF is a key regulator of human CYP7A gene expression in the liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.