ArticleProceedings of the National Academy of Sciences of the United States of America1999
Solution structure of a DNA decamer duplex containing the stable 3' T.G base pair of the pyrimidine(6-4)pyrimidone photoproduct [(6-4) adduct]: implications for the highly specific 3' T --> C transition of the (6-4) adduct.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ.Life science alliance · 2021Article
- DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins.Cell cycle (Georgetown, Tex.) · 2020Article
- Conformational polymorphism or structural invariance in DNA photoinduced lesions: implications for repair rates.Nucleic acids research · 2017Article
- Both DNA global deformation and repair enzyme contacts mediate flipping of thymine dimer damage.Scientific reports · 2017Article
- Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.Science advances · 2016Article
- Genetic Control of Replication through N1-methyladenine in Human Cells.The Journal of biological chemistry · 2015Article
- Photochemistry and Photobiology of the Spore Photoproduct: A 50-Year Journey.Photochemistry and photobiology · 2015Review
- Structural biology of DNA (6-4) photoproducts formed by ultraviolet radiation and interactions with their binding proteins.International journal of molecular sciences · 2014Review
- The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.Journal of nucleic acids · 2010Article
- Error-free replicative bypass of (6-4) photoproducts by DNA polymerase zeta in mouse and human cells.Genes & development · 2010Article
- NMR structure of the DNA decamer duplex containing double T*G mismatches of cis-syn cyclobutane pyrimidine dimer: implications for DNA damage recognition by the XPC-hHR23B complex.Nucleic acids research · 2004Article
- Male-biased transmission of deleterious mutations to the progeny in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol.Genes & development · 2003Article
- Lesion bypass in yeast cells: Pol eta participates in a multi-DNA polymerase process.The EMBO journal · 2002Article
- UV-induced T-->C transition at a TT photoproduct site is dependent on Saccharomyces cerevisiae polymerase eta in vivo.Nucleic acids research · 2002Article
- DNA repair of a single UV photoproduct in a designed nucleosome.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct.Molecular and cellular biology · 2001Article
- Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts.Molecular and cellular biology · 2001Article
- The Dewar photoproduct of thymidylyl(3'-->5')- thymidine (Dewar product) exhibits mutagenic behavior in accordance with the "A rule".Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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3 authors.
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Abstract
The pyrimidine(6-4)pyrimidone photoproduct [(6-4) adduct] is one of the major photoproducts induced by UV irradiation of DNA and occurs at TpT sites. The (6-4) adduct is highly mutagenic and leads most often to a 3' T --> C transition with 85% replicating error frequency [LeClerc, J. E., Borden, A. & Lawrence, C. W. (1991) Proc. Natl. Acad. Sci. USA 88, 9685-9689]. To determine the origin of the specific 3' T --> C transition of the (6-4) adduct, we have used experimental NMR restraints and molecular dynamics to determine the solution structure of a (6-4)-lesion DNA decamer duplex that contains a mismatched base pair between the 3' T residue and an opposed G residue. Normal Watson-Crick-type hydrogen bonding is retained at the 5' T of the lesion site. The O2 carbonyl of the 3' T residue forms hydrogen bonds with the imino and amino protons of the opposed G residue. This potential hydrogen bonding stabilizes the overall helix and restores the highly distorted conformation of the (6-4) adduct to the typical B-form-like DNA structure. This structural feature can explain the marked preference for the insertion of an A residue opposite the 5' T and a G residue opposite the 3' T of the (6-4) lesion during trans-lesion synthesis. Thus these insertions yield the predominant 3' T --> C transition.
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