ArticleMolecular biology of the cell1999
Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 109 citations in OpenAlex.
- PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms.Journal of virology · 2026Article
- Zellweger syndrome; identification of mutations inAnnals of medicine · 2025Article
- Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action.Research square · 2024Article
- Peroxisome Proliferator FpPEX11 Is Involved in the Development and Pathogenicity inInternational journal of molecular sciences · 2022Article
- Peroxisome function relies on organelle-associated mRNA translation.Science advances · 2022Article
- Article
- Post-translational modifications of proteins associated with yeast peroxisome membrane: An essential mode of regulatory mechanism.Genes to cells : devoted to molecular & cellular mechanisms · 2021Review
- Nitrogen Starvation and Stationary Phase Lipophagy Have Distinct Molecular Mechanisms.International journal of molecular sciences · 2020Article
- Peroxisome biogenesis, membrane contact sites, and quality control.EMBO reports · 2019Review
- Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis.The Journal of biological chemistry · 2017Article
- The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.PloS one · 2016Article
- Peroxisomal Pex3 activates selective autophagy of peroxisomes via interaction with the pexophagy receptor Atg30.The Journal of biological chemistry · 2015Article
- Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy.The Journal of cell biology · 2014Article
- Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.The Journal of cell biology · 2013Article
- Phosphorylation-dependent Pex11p and Fis1p interaction regulates peroxisome division.Molecular biology of the cell · 2012Article
- Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance.British journal of pharmacology · 2011Review
- Peroxisome assembly: matrix and membrane protein biogenesis.The Journal of cell biology · 2011Review
- Atg35, a micropexophagy-specific protein that regulates micropexophagic apparatus formation in Pichia pastoris.Autophagy · 2011Article
- Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.The Journal of biological chemistry · 2009Article
- Dysferlin domain-containing proteins, Pex30p and Pex31p, localized to two compartments, control the number and size of oleate-induced peroxisomes in Pichia pastoris.Molecular biology of the cell · 2008Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We report the cloning and characterization of Pichia pastoris PEX19 by complementation of a peroxisome-deficient mutant strain. Import of peroxisomal targeting signal 1- and 2-containing peroxisomal matrix proteins is defective in pex19 mutants. PEX19 encodes a hydrophilic 299-amino acid protein with sequence similarity to Saccharomyces cerevisiae Pex19p and human and Chinese hamster PxF, all farnesylated proteins, as well as hypothetical proteins from Caenorhabditis elegans and Schizosaccharomyces pombe. The farnesylation consensus is conserved in PpPex19p but dispensable for function and appears unmodified under the conditions tested. Pex19p localizes predominantly to the cytosolic fraction. Biochemical and two-hybrid analyses confirmed that Pex19p interacts with Pex3p, as seen in S. cerevisiae, but unexpectedly also with Pex10p. Two-hybrid analysis demonstrated that the amino-terminal 42 amino acids of Pex19p interact with the carboxyl-terminal 335 amino acids of Pex3p. In addition, the extreme carboxyl terminus of Pex19p (67 amino acids) is required for interaction with the amino-terminal 380 amino acids of Pex10p. Biochemical and immunofluorescence microscopy analyses of pex19Delta cells identified the membrane protein Pex3p in peroxisome remnants that were not previously observed in S. cerevisiae. These small vesicular and tubular (early) remnants are morphologically distinct from other Pppex mutant (late) remnants, suggesting that Pex19p functions at an early stage of peroxisome biogenesis.
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