ArticleMolecular biology of the cell1999
Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- NAT10 triggers colorectal cancer progression via promoting PPAN-regulated DNA damage repair.Oncogene · 2026Article
- NOC1 is a direct MYC target, and its protein interactome dissects its activity in controlling nucleolar function.Frontiers in cell and developmental biology · 2023Article
- An SNP reducing SNORD105 and PPAN expression decreases the risk of hepatocellular carcinoma in a Chinese population.Journal of clinical laboratory analysis · 2021Article
- Article
- Liver X Receptor-Binding DNA Motif Associated With Atherosclerosis-Specific DNA Methylation Profiles ofJournal of the American Heart Association · 2018Article
- Transcriptome Profiling of Tiller Buds Provides New Insights into PhyB Regulation of Tillering and Indeterminate Growth in Sorghum.Plant physiology · 2016Article
- The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway.The Journal of biological chemistry · 2015Article
- Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila.PloS one · 2013Article
- Cell competition and its implications for development and cancer.Journal of genetics and genomics = Yi chuan xue bao · 2011Review
- The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior.PloS one · 2010Article
- Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.Developmental biology · 2010Article
- CAF-1 is required for efficient replication of euchromatic DNA in Drosophila larval endocycling cells.Chromosoma · 2009Article
- Article
- Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth.Genes & development · 2005Article
- Article
- Gene expression patterns associated with blood-feeding in the malaria mosquito Anopheles gambiae.BMC genomics · 2005Article
- Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth.Molecular and cellular biology · 2002Article
- The ryanodine receptor is essential for larval development in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
We identified a new Drosophila gene, peter pan (ppan), in a screen for larval growth-defective mutants. ppan mutant larvae do not grow and show minimal DNA replication but can survive until well after their heterozygotic siblings have pupariated. We cloned the ppan gene by P-element plasmid rescue. ppan belongs to a highly conserved gene family that includes Saccharomyces cerevisiae SSF1 and SSF2, as well as Schizosaccharomyces pombe, Arabidopsis, Caenorhabditis elegans, mouse, and human homologues. Deletion of both SSF1 and SSF2 in yeast is lethal, and depletion of the gene products causes cell division arrest. Mosaic analysis of ppan mutant clones in Drosophila imaginal disks and ovaries demonstrates that ppan is cell autonomous and required for normal mitotic growth but is not absolutely required for general biosynthesis or DNA replication. Overexpression of the wild-type gene causes cell death and disrupts the normal development of adult structures. The ppan gene family appears to have an essential and evolutionarily conserved role in cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.