ArticleThe Journal of experimental medicine1999
bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 132 citations in OpenAlex.
- EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.Nature communications · 2021Trial
- The broad impact of cell death genes on the human disease phenome.Cell death & disease · 2024Article
- What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?Cell death and differentiation · 2022Review
- Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesisHaematologica · 2021Article
- Alternative splicing ofOncology letters · 2021Review
- Article
- Role of Extrinsic Apoptotic Signaling Pathway during Definitive Erythropoiesis in Normal Patients and in Patients with β-Thalassemia.International journal of molecular sciences · 2020Review
- BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells.Cell death & disease · 2020Article
- Targeting the Bcl-2 Family in B Cell Lymphoma.Frontiers in oncology · 2018Review
- The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.Cell death & disease · 2017Article
- Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members.The FEBS journal · 2016Review
- Harnessing the apoptotic programs in cancer stem-like cells.EMBO reports · 2015Review
- Apoptosis: role in myeloid cell development.Blood research · 2015Review
- Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.The FEBS journal · 2015Review
- Mitochondria-mediated apoptosis in mammals.Protein & cell · 2014Article
- Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts.Haematologica · 2013Article
- BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis.Apoptosis : an international journal on programmed cell death · 2013Article
- Mesodermal and hematopoietic differentiation from ES and iPS cells.Stem cell reviews and reports · 2013Review
- Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells.Stem cell research & therapy · 2013Review
- Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.Genes & development · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
bcl-x is a member of the bcl-2 gene family, which regulates apoptotic cell death in various cell lineages. There is circumstantial evidence suggesting that bcl-x might play a role in the apoptosis of erythroid lineage cells, although there is no direct evidence. In this study, we used Bcl-X null mouse embryonic stem (ES) cells, and showed that Bcl-X is indispensable for the production of both embryonic primitive erythrocytes (EryP) and adult definitive erythrocytes (EryD) at the end of their maturation. In vivo, bcl-x-/- ES cells did not contribute to circulating EryD in adult chimeric mice that were produced by blastocyst microinjection of the bcl-x-/- ES cells. bcl-x-/- EryP and EryD were produced by in vitro differentiation induction of ES cells on macrophage colony-stimulating factor-deficient stromal cell line OP9, and further analysis was carried out. The emergence of immature EryP and EryD from bcl-x-/- ES cells was similar to that from bcl-x+/+ ES cells. However, prominent cell death of bcl-x-/- EryP and EryD occurred when the cells matured. The data show that the antiapoptotic function of bcl-x acts at the very end of erythroid maturation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.