ArticleJapanese journal of cancer research : Gann1999
Expression of fibronectin isoforms in human breast tissue: production of extra domain A+/extra domain B+ by cancer cells and extra domain A+ by stromal cells.
Article in Japanese journal of cancer research : Gann, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- EDB-FN-targeted probes for near infrared fluorescent imaging and positron emission tomography imaging of breast cancer in mice.Scientific reports · 2024Article
- A positive feedback loop driven by fibronectin and IL-1β sustains the inflammatory microenvironment in breast cancer.Breast cancer research : BCR · 2023Article
- PET Imaging of Hepatocellular Carcinoma Using ZD2-(Journal of hepatocellular carcinoma · 2023Article
- Review
- Macrophages and Extracellular Matrix in Breast Cancer: Partners in Crime or Protective Allies?Frontiers in oncology · 2021Review
- Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase.Matrix biology plus · 2020Article
- Overexpression of Extradomain-B Fibronectin is Associated with Invasion of Breast Cancer Cells.Cells · 2020Article
- Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling.Matrix biology : journal of the International Society for Matrix Biology · 2020Article
- Preparation and Evaluation of ZD2 PeptideACS omega · 2019Article
- EDB Fibronectin-Specific SPECT ProbeACS omega · 2017Article
- Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe.Scientific reports · 2016Article
- FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling.Science translational medicine · 2014Article
- Differences between the early and advanced stages of rheumatoid arthritis in the expression of EDA-containing fibronectin.Rheumatology international · 2009Article
- Fibronectins in vascular morphogenesis.Angiogenesis · 2009Review
- Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors.Breast cancer research : BCR · 2007Article
- Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury.The American journal of pathology · 2005Article
- Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture.Breast cancer research : BCR · 2005Article
- Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis.Molecular and cellular biology · 2004Article
- Involvement of large tenascin-C splice variants in breast cancer progression.The American journal of pathology · 2003Article
- PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of fibronectin (FN) isoforms including extra domain A (EDA) and extra domain B (EDB) segments, was investigated in 36 invasive ductal carcinomas and 13 benign tumors of human breast tissues by in situ hybridization using probes specific to alternative splicing sites. Signals for the constant region of FN mRNA in cancer cells were found in 53% of the invasive ductal carcinomas. The EDA+ and EDB+ mRNA signals were found in 47% and 33%, respectively. Stromal cells expressing FN, EDA+ and EDB+ mRNA signals were present in 100%, 69% and 14% of cases, respectively. Expression of FN mRNAs by cancer cells was most frequent in intraductal lesions or large cancer nests, and that by stromal cells was associated with desmoplastic areas. In representative cases, proportions of FN mRNA-positive cancer cells expressing EDA and EDB segments were 45% and 39%, respectively, signals for both being frequently found in the same cells. EDA+ and EDB+ mRNA were labeled in 25% and 6% of the FN mRNA-positive stromal cells, a large proportion thus being EDA-/EDB- FN. In conclusion, the splicing pattern of FN pre-mRNA is dependent on the cell type and histology of breast cancer tissues. The observed lack of expression in fibroadenomas and other benign conditions suggests a link with tumor progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.