ArticleThe Journal of physiology1999
Does the guinea-pig ileum obey the 'law of the intestine'?
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- An Engineered Living Intestinal Muscle Patch Produces Macroscopic Contractions that can Mix and Break Down Artificial Intestinal Contents.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- The enteric nervous system.Physiological reviews · 2023Review
- Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon.Frontiers in physiology · 2020Article
- Embryogenesis of the peristaltic reflex.The Journal of physiology · 2019Article
- Spatiotemporal Mapping of the Contracting Gravid Uterus of the Rabbit Shows Contrary Changes With Increasing Gestation and Dosage With Oxytocin.Frontiers in endocrinology · 2019Article
- Quantifying Patterns of Smooth Muscle Motility in the Gut and Other Organs With New Techniques of Video Spatiotemporal Mapping.Frontiers in physiology · 2018Article
- Electrical stimulation of gut motility guided by an in silico model.Journal of neural engineering · 2017Article
- Mechanosensitivity in the enteric nervous system.Frontiers in cellular neuroscience · 2015Review
- Nitric oxide regulates polarity of guinea pig distal colon pellet propagation and circular muscle motor response.Journal of gastroenterology · 2014Article
- Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis.Frontiers in neuroscience · 2014Article
- Article
- Regulation of gastrointestinal motility--insights from smooth muscle biology.Nature reviews. Gastroenterology & hepatology · 2012Review
- Two independent networks of interstitial cells of cajal work cooperatively with the enteric nervous system to create colonic motor patterns.Frontiers in neuroscience · 2011Article
- Neuroeffector apparatus in gastrointestinal smooth muscle organs.The Journal of physiology · 2010Review
- Colonic elongation inhibits pellet propulsion and migrating motor complexes in the murine large bowel.The Journal of physiology · 2010Article
- Purinergic mechanisms in the control of gastrointestinal motility.Purinergic signalling · 2008Article
- Characterization of flow and mixing regimes within the ileum of the brushtail possum using residence time distribution analysis with simultaneous spatio-temporal mapping.The Journal of physiology · 2007Article
- High definition mapping of circular and longitudinal motility in the terminal ileum of the brushtail possum Trichosurus vulpecula with watery and viscous perfusates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
- Synaptic transmission at functionally identified synapses in the enteric nervous system: roles for both ionotropic and metabotropic receptors.Current neuropharmacology · 2007Article
- Translating Trendelenburg; back to the future.Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
1. We report the first simultaneous mechanical reflex responses of the longitudinal muscle (LM) and circular muscle (CM) layers of the guinea-pig ileum following mucosal stimulation and distension in vitro. 2. Dissection techniques were used to prevent mechanical interaction between the LM and CM layers both oral and anal to a stimulus site. 3. All graded stimuli produced graded contractions of both the LM and CM orally and anally to the stimulus. Contractions occurred synchronously in the LM and CM and under no circumstances were inhibitory responses recorded in either muscle layer, despite the presence of ongoing cholinergic tone in both the LM and CM. Contractions were abolished by tetrodotoxin (1.6 microM). 4. Local brush stroking of the mucosa evoked a peristaltic wave which readily conducted distally over 13 cm, without the presence of fluid in the lumen. No descending relaxation was observed. 5. Apamin (300 nM) disrupted evoked peristaltic waves and significantly increased the rate-of-rise of the LM and CM contractions anal to a stimulus, and the LM oral to a stimulus. 6. Nomega-nitro-L-arginine (100 microM), a nitric oxide synthesis inhibitor, had no overall significant effect on the characteristics of the LM and CM contractions, although on occasion an enhancement in their peak amplitude was noted. 7. It is suggested that the guinea-pig ileum does not conform to the 'law of the intestine' as postulated by Bayliss & Starling (1899). Rather, local physiological stimulation of the ileum elicits a contraction both orally and anally to a stimulus, which occurs synchronously in both the CM and LM layers. Apamin-sensitive inhibitory neurotransmission modulates the rate-of-rise of the anal contraction of the CM, possibly to generate distal propulsion.
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Registered trials
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