ArticleThe Journal of physiology1999
Noradrenaline synchronizes evoked quantal release at frog neuromuscular junctions.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
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- Microelectrode-based approaches for studying cholinergic neuromuscular transmission.Biophysical reviews · 2025Review
- From Frog Muscle to Brain Neurons: Joys and Sorrows in Neuroscience.Physiological research · 2024Review
- The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions.Neurochemical research · 2024Article
- Early Alterations in Structural and Functional Properties in the Neuromuscular Junctions of Mutant FUS Mice.International journal of molecular sciences · 2023Article
- L-type CaCellular and molecular neurobiology · 2022Article
- Presynaptic Acetylcholine Receptors Modulate the Time Course of Action Potential-Evoked Acetylcholine Quanta Secretion at Neuromuscular Junctions.Biomedicines · 2022Review
- Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction.International journal of molecular sciences · 2021Review
- Adrenaline Facilitates Synaptic Transmission by Synchronizing Release of Acetylcholine Quanta from Motor Nerve Endings.Cellular and molecular neurobiology · 2021Article
- Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type CaMolecular and cellular neurosciences · 2019Article
- Bayesian analysis of the kinetics of quantal transmitter secretion at the neuromuscular junction.Journal of computational neuroscience · 2015Article
- Septin dynamics are essential for exocytosis.The Journal of biological chemistry · 2015Article
- Article
- Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Cholinergic regulation of the evoked quantal release at frog neuromuscular junction.The Journal of physiology · 2004Article
- Dual action of hydrogen peroxide on synaptic transmission at the frog neuromuscular junction.The Journal of physiology · 2003Article
- Temperature effect on proximal to distal gradient of quantal release of acetylcholine at frog endplate.Neurochemical research · 2003Article
- Protein kinase A cascade regulates quantal release dispersion at frog muscle endplate.The Journal of physiology · 2002Article
- Different mechanisms control the amount and time course of neurotransmitter release.The Journal of physiology · 1999Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Noradrenaline (NA) increases synaptic efficacy at the frog neuromuscular junction. To test the hypothesis that one of the actions of NA is to shorten the period over which evoked quanta are released, we measured the latencies of focally recorded uniquantal endplate currents (EPCs). 2. NA shortened the release period for evoked quantal release. The interval between the time when responses with minimal delay appeared and the point at which 90 % of all latencies had occurred was shortened in the presence of 1 x 10-5 M NA by about 35 % at 20 C and by about 45 % at 8 C. Inhibitor and agonist experiments showed that NA acts on a beta-adrenoreceptor. 3. The better synchronization of release significantly increased the size of reconstructed multi- quantal EPCs. This suggests that NA facilitates synaptic transmission by making the release of quanta more synchronous. 4. The synchronizing action of NA might potentiate neuromuscular transmission during nerve regeneration, transmitter exhaustion and other extreme physiological states where the quantal content is reduced, such as survival in cold and hibernation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.