ArticleDevelopment (Cambridge, England)1999
POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression.
Article in Development (Cambridge, England), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 124 citations in OpenAlex.
- Multiple glycoforms of TrkA interact with N-cadherin during trigeminal ganglion neurodevelopment.Journal of cell science · 2026Article
- Zebrafish pou3f3b controls saccular/auditory development and marks non-neuronal cells that delaminate from the otic vesicle to promote neuroblast maturation.Developmental biology · 2026Article
- The transcriptional landscape of the developing chick trigeminal ganglion.Developmental biology · 2025Article
- Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia.eLife · 2022Article
- Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification.Neural development · 2021Article
- High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New "Histo3D" System.Biomedicines · 2021Article
- Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model.Gene therapy · 2020Article
- Retinal ganglion cell defects cause decision shifts in visually evoked defense responses.Journal of neurophysiology · 2020Article
- Ret Signaling Is Required for Tooth Pulp Innervation during Organogenesis.Journal of dental research · 2019Article
- Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins.Cell transplantation · 2018Review
- Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret.The Journal of comparative neurology · 2018Article
- Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons.Genes & development · 2016Article
- Dynamic expression of transcription factor Brn3b during mouse cranial nerve development.The Journal of comparative neurology · 2016Article
- Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia.Cellular and molecular neurobiology · 2015Article
- Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Activation of Six1 Expression in Vertebrate Sensory Neurons.PloS one · 2015Article
- Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.PloS one · 2014Article
- Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants.Stem cells and development · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Mice lacking the POU domain-containing transcription factor Brn-3a have several neuronal deficits. In the present paper, we show that Brn-3a plays two distinct roles during development of the trigeminal ganglion. In this ganglion, neurons expressing the neurotrophin receptors, TrkB and TrkC, are born between E9.5 and E11.5. In the absence of Brn-3a, very few neurons ever express TrkC, but TrkB-expressing neurons are present at E12.5 in elevated numbers, suggesting that Brn-3a may be a constituent of a regulatory circuit determining which Trk receptor is expressed by these early-born neurons. Most neurons expressing the neurotrophin receptor TrkA are generated between E11.5 and E13.5 in this ganglion and their initial generation is not prevented by absence of Brn-3a. However, after E12. 5, absence of Brn-3a results in a progressive loss in neuronal TrkA and TrkB expression, which leads to a massive wave of apoptosis that peaks at E15.5. Despite complete absence of the Trk receptors at E17. 5 and P0, approximately 30% of the normal complement of neurons survive to birth in Brn-3a mutants. Approximately 70% of these express the GDNF receptor subunit, c-ret; many can be sustained by GDNF, but not by NGF in culture. Thus, the vast majority of surviving neurons are probably sustained in vivo by trophic factor(s) whose receptors are not regulated by Brn-3a. In conclusion, our data indicate the specific functions of Brn-3a in controlling the survival and differentiation of trigeminal neurons by regulating expression of each of the three Trk receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.