ReviewMicrobiology and molecular biology reviews : MMBR1999
PAS domains: internal sensors of oxygen, redox potential, and light.
Review in Microbiology and molecular biology reviews : MMBR, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 676 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
676 citing papers in PubMed.
- Signaling mechanism of the transmembrane energy receptor Aer.bioRxiv : the preprint server for biology · 2026Article
- Function and transcription of stoS gene of Xanthomonas campestris pathovar campestris.Antonie van Leeuwenhoek · 2026Article
- Structural Basis of a Novel Heme Binding Bacterial One-Component Switch.bioRxiv : the preprint server for biology · 2026Article
- Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets.FEBS letters · 2026Review
- Integrative Structural Characterization ofACS omega · 2026Article
- A bacterial NO-binding sensor domain evolved through acquisition of a cytochrome-derived c-type heme-binding motif.bioRxiv : the preprint server for biology · 2026Article
- Functional insights into the photoactive yellow protein family from homologs, multidomain proteins, and inferredJournal of bacteriology · 2026Review
- Flowering time regulation: a critical review focusing on FKF1 protein.Plant molecular biology · 2026Review
- From photosynthetic electron flow to gene regulation: redox signal transduction in cyanobacteria.FEMS microbiology reviews · 2026Review
- Architecture and regulatory functions of c-di-GMP signaling in classical Bordetella species.FEMS microbiology reviews · 2026Review
- Review
- ssDNA phage FLiP resides in dsDNA form in resistant Flavobacterium host.Biology direct · 2025Article
- Two-component systems as potential therapeutic targets inAnnals of medicine · 2025Review
- Article
- Use of High Pressure NMR Spectroscopy to Rapidly Identify Proteins with Internal Ligand-Binding Voids.bioRxiv : the preprint server for biology · 2025Article
- Diverse bacteriohemerythrin genes ofmBio · 2025Article
- A pipeline for screening small molecule-enhanced protein stability in a bacterial orphan receptor.Protein science : a publication of the Protein Society · 2025Article
- Sensing the Reducing Power to Determine the Cell Fate: Flavin Redox-Switches in Signal Transduction.Current microbiology · 2025Review
- The virulence regulatorJournal of bacteriology · 2025Article
- Cyanobacterial scytonemin, a potential photoprotective natural pigment: biomedical, industrial and environmental applications.Archives of microbiology · 2025Review
616 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
PAS domains are newly recognized signaling domains that are widely distributed in proteins from members of the Archaea and Bacteria and from fungi, plants, insects, and vertebrates. They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli. Specificity in sensing arises, in part, from different cofactors that may be associated with the PAS fold. Transduction of redox signals may be a common mechanistic theme in many different PAS domains. PAS proteins are always located intracellularly but may monitor the external as well as the internal environment. One way in which prokaryotic PAS proteins sense the environment is by detecting changes in the electron transport system. This serves as an early warning system for any reduction in cellular energy levels. Human PAS proteins include hypoxia-inducible factors and voltage-sensitive ion channels; other PAS proteins are integral components of circadian clocks. Although PAS domains were only recently identified, the signaling functions with which they are associated have long been recognized as fundamental properties of living cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.