ReviewMicrobiology and molecular biology reviews : MMBR1999
DNA bending and wrapping around RNA polymerase: a "revolutionary" model describing transcriptional mechanisms.
Review in Microbiology and molecular biology reviews : MMBR, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 120 citations in OpenAlex.
- Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review).Molecular medicine reports · 2026Review
- Landscape of transcription termination in Arabidopsis revealed by single-molecule nascent RNA sequencing.Genome biology · 2021Article
- Cruciform Formable Sequences withinInternational journal of molecular sciences · 2021Article
- Metalloregulator CueR biases RNA polymerase's kinetic sampling of dead-end or open complex to repress or activate transcription.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- New insights into the regulatory mechanisms of ppGpp and DksA on Escherichia coli RNA polymerase-promoter complex.Nucleic acids research · 2015Article
- Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers.Nature genetics · 2014Article
- Unusual interaction of RNA polymerase with the bacteriophage Mu middle promoter Pm in the absence of its activator protein Mor.MicrobiologyOpen · 2014Article
- Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2.Nucleic acids research · 2013Article
- Single-molecule spectroscopic study of dynamic nanoscale DNA bending behavior of HIV-1 nucleocapsid protein.The journal of physical chemistry. B · 2013Article
- Indirect read-out of the promoter DNA by RNA polymerase in the closed complex.Nucleic acids research · 2013Article
- Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase.The Journal of biological chemistry · 2011Article
- Comparing binding site information to binding affinity reveals that Crp/DNA complexes have several distinct binding conformers.Nucleic acids research · 2011Article
- The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.Molecular & cellular proteomics : MCP · 2010Article
- New insights into the biogenesis of nuclear RNA polymerases?Biochemistry and cell biology = Biochimie et biologie cellulaire · 2010Review
- Sequence-dependent upstream DNA-RNA polymerase interactions in the open complex with lambdaPR and lambdaPRM promoters and implications for the mechanism of promoter interference.Journal of molecular biology · 2009Article
- Use of site-specific protein-DNA photocrosslinking of purified complexes to analyze the topology of the RNA polymerase II transcription initiation complex.Methods in molecular biology (Clifton, N.J.) · 2009Article
- MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity.The Journal of biological chemistry · 2008Article
- Structural characterization of human general transcription factor TFIIF in solution.Protein science : a publication of the Protein Society · 2008Article
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.Molecular cell · 2007Article
- Upstream promoter sequences and alphaCTD mediate stable DNA wrapping within the RNA polymerase-promoter open complex.EMBO reports · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
A model is proposed in which bending and wrapping of DNA around RNA polymerase causes untwisting of the DNA helix at the RNA polymerase catalytic center to stimulate strand separation prior to initiation. During elongation, DNA bending through the RNA polymerase active site is proposed to lower the energetic barrier to the advance of the transcription bubble. Recent experiments with mammalian RNA polymerase II along with accumulating evidence from studies of Escherichia coli RNA polymerase indicate the importance of DNA bending and wrapping in transcriptional mechanisms. The DNA-wrapping model describes specific roles for general RNA polymerase II transcription factors (TATA-binding protein [TBP], TFIIB, TFIIF, TFIIE, and TFIIH), provides a plausible explanation for preinitiation complex isomerization, suggests mechanisms underlying the synergy between transcriptional activators, and suggests an unforseen role for TBP-associating factors in transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.