ArticleBiophysical journal1999
Lipid flow through fusion pores connecting membranes of different tensions.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Friction-driven scission: How nonlocal mechanisms contribute to membrane fission across domains of life.Science advances · 2026Review
- Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction.Nature cell biology · 2026Article
- Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo.The Journal of cell biology · 2024Article
- The yellow brick road to nuclear membrane mechanotransduction.APL bioengineering · 2022Review
- Components and Mechanisms of Nuclear Mechanotransduction.Annual review of cell and developmental biology · 2021Review
- Large-scale simulation of biomembranes incorporating realistic kinetics into coarse-grained models.Nature communications · 2020Article
- Visualization of expanding fusion pores in secretory cells.The Journal of general physiology · 2018Review
- SNARE-mediated membrane fusion arrests at pore expansion to regulate the volume of an organelle.The EMBO journal · 2018Article
- The Actomyosin Cytoskeleton Drives Micron-Scale Membrane Remodeling In Vivo Via the Generation of Mechanical Forces to Balance Membrane Tension Gradients.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Fusion pores and their control of neurotransmitter and hormone release.The Journal of general physiology · 2017Review
- Article
- Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- Linking differences in membrane tension with the requirement for a contractile actomyosin scaffold during exocytosis in salivary glands.Communicative & integrative biology · 2012Article
- SNARE complex zipping as a driving force in the dilation of proteinaceous fusion pores.The Journal of membrane biology · 2010Article
- Intermonolayer friction and surface shear viscosity of lipid bilayer membranes.Biophysical journal · 2007Article
- Surface viscosity, diffusion, and intermonolayer friction: simulating sheared amphiphilic bilayers.Biophysical journal · 2005Article
- Tension in tubulovesicular networks of Golgi and endoplasmic reticulum membranes.Biophysical journal · 2004Article
- The effects of vesicular volume on secretion through the fusion pore in exocytotic release from PC12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Artificial cells: unique insights into exocytosis using liposomes and lipid nanotubes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Membrane fusion: stalk model revisited.Biophysical journal · 2002Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
When two membranes fuse, their components mix; this is usually described as a purely diffusional process. However, if the membranes are under different tensions, the material will spread predominantly by convection. We use standard fluid mechanics to rigorously calculate the steady-state convective flux of lipids. A fusion pore is modeled as a toroid shape, connecting two planar membranes. Each of the membrane monolayers is considered separately as incompressible viscous media with the same shear viscosity, etas. The two monolayers interact by sliding past each other, described by an intermonolayer viscosity, etar. Combining a continuity equation with an equation that balances the work provided by the tension difference, Deltasigma, against the energy dissipated by flow in the viscous membrane, yields expressions for lipid velocity, upsilon, and area of lipid flux, Phi. These expressions for upsilon and Phi depend on Deltasigma, etas, etar, and geometrical aspects of a toroidal pore, but the general features of the theory hold for any fusion pore that has a roughly hourglass shape. These expressions are readily applicable to data from any experiments that monitor movement of lipid dye between fused membranes under different tensions. Lipid velocity increases nonlinearly from a small value for small pore radii, rp, to a saturating value at large rp. As a result of velocity saturation, the flux increases linearly with pore radius for large pores. The calculated lipid flux is in agreement with available experimental data for both large and transient fusion pores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.