ArticleBiophysical journal1999
Spermine and arcaine block and permeate N-methyl-D-aspartate receptor channels.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Enhancement of hippocampal synaptic AMPA receptor function by the antidepressant tianeptine and by opioid peptides.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Intracellular Spermine Is a Key Player in GSG1L's Regulation of Calcium-Permeable AMPAR Channel Conductance and Recovery from Desensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- TwoeLife · 2021Article
- Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons.eLife · 2018Article
- Spermine Condenses DNA, but Not RNA Duplexes.Biophysical journal · 2017Article
- The role of glia in stress: polyamines and brain disorders.The Psychiatric clinics of North America · 2014Review
- Anti-inflammatory role of fetuin-A in injury and infection.Current molecular medicine · 2012Review
- Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2010Article
- Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential.British journal of pharmacology · 2009Review
- N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.Neuropharmacology · 2008Article
- Activation of extrasynaptic NMDA receptors induces a PKC-dependent switch in AMPA receptor subtypes in mouse cerebellar stellate cells.The Journal of physiology · 2007Article
- Nitric oxide is involved in the memory facilitation induced by spermidine in rats.Psychopharmacology · 2006Article
- Effects of polyamines on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle myocytes.British journal of pharmacology · 2004Article
- Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Polyvalent cations as permeant probes of MIC and TRPM7 pores.Biophysical journal · 2003Article
- Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- A molecular link between inward rectification and calcium permeability of neuronal nicotinic acetylcholine alpha3beta4 and alpha4beta2 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines: a possible basis for modulation of excitability in vivo.Channels (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Polyamines such as spermine are thought to be endogenous regulators of NMDA (N-methyl-D-aspartate)-type glutamate receptors. Polyamine block of NMDA receptors was studied in excised outside-out patches from rat hippocampal neurons and Xenopus oocytes expressing recombinant receptors. Extracellular spermine and arcaine reduced NMDA single-channel conductance in a voltage-dependent manner, with partial relief of block evident at large inside negative membrane potentials. Reducing extracellular Na+ concentration increased the apparent affinities for spermine and arcaine, indicating strong interaction between spermine and permeant ions. Internal spermine also blocked NMDA channels in a voltage-dependent manner, with relief of block evident at large inside positive potentials. The Woodhull model of channel block by an impermeant ion adequately described the actions of external spermine from -60 to +60 mV, but failed for more negative potentials. Eyring rate theory for a permeable blocker with two barriers and one binding site adequately described the voltage-dependent block and relief from block by both external and internal spermine over the range of -120 to +60 mV. These findings indicate that polyamines block and permeate neuronal NMDA receptor channels from the extracellular and intracellular sides, although sensitivity to internal spermine is probably too low to be physiologically relevant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.