ArticleGenetics1999
MOD-D, a Galpha subunit of the fungus Podospora anserina, is involved in both regulation of development and vegetative incompatibility.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Plants interfere with non-self recognition of a phytopathogenic fungus via proline accumulation to facilitate mycovirus transmission.Nature communications · 2024Article
- Genetics of Adaptation of the Ascomycetous Fungus Podospora anserina to Submerged Cultivation.Genome biology and evolution · 2019Article
- Virus-mediated suppression of host non-self recognition facilitates horizontal transmission of heterologous viruses.PLoS pathogens · 2017Article
- Trans-species activity of a nonself recognition domain.BMC microbiology · 2013Article
- Genetic and physical interactions between Gα subunits and components of the Gβγ dimer of heterotrimeric G proteins in Neurospora crassa.Eukaryotic cell · 2012Article
- A G alpha subunit gene is essential for conidiation and potassium efflux but dispensable for pathogenicity of Alternaria alternata on citrus.Current genetics · 2010Article
- Light-dependent roles of the G-protein alpha subunit GNA1 of Hypocrea jecorina (anamorph Trichoderma reesei).BMC biology · 2009Article
- Sexual and vegetative compatibility genes in the aspergilli.Studies in mycology · 2007Article
- Control of canalization and evolvability by Hsp90.PloS one · 2006Article
- Article
- Comparative analysis of programmed cell death pathways in filamentous fungi.BMC genomics · 2005Article
- Developmental and transcriptional responses to host and nonhost cuticles by the specific locust pathogen Metarhizium anisopliae var. acridum.Eukaryotic cell · 2005Article
- Signal transduction by Tga3, a novel G protein alpha subunit of Trichoderma atroviride.Applied and environmental microbiology · 2005Article
- Analysis of altered G-protein subunit accumulation in Cryphonectria parasitica reveals a third Galpha homologue.Current genetics · 2003Article
- Fatal attraction: nonself recognition and heterokaryon incompatibility in filamentous fungi.Eukaryotic cell · 2003Review
- Shared and independent roles for a Galpha(i) protein and adenylyl cyclase in regulating development and stress responses in Neurospora crassa.Eukaryotic cell · 2002Article
- Trichoderma atroviride G-protein alpha-subunit gene tga1 is involved in mycoparasitic coiling and conidiation.Eukaryotic cell · 2002Article
- Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.Molecular and cellular biology · 2001Article
- Genomic evidence for a complete sexual cycle in Candida albicans.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Signal transduction cascades regulating fungal development and virulence.Microbiology and molecular biology reviews : MMBR · 2000Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell death via vegetative incompatibility is widespread in fungi but molecular mechanism and biological function of the process are poorly understood. One way to investigate this phenomenon was to study genes named mod that modified incompatibility reaction. In this study, we cloned the mod-D gene that encodes a Galpha protein. The mod-D mutant strains present developmental defects. Previously, we showed that the mod-E gene encodes an HSP90. The mod-E1 mutation suppresses both vegetative incompatibility and developmental defects due to the mod-D mutation. Moreover, we isolated the PaAC gene, which encodes an adenylate cyclase, as a partial suppressor of the mod-D1 mutation. Our previous results showed that the molecular mechanisms involved in vegetative incompatibility and developmental pathways are connected, suggesting that vegetative incompatibility may result from disorders in some developmental steps. Our new result corroborates the involvement of mod genes in signal transduction pathways. As expected, we showed that an increase in the cAMP level is able to suppress the defects in vegetative growth due to the mod-D1 mutation. However, cAMP increase has no influence on the suppressor effect of the mod-D1 mutation on vegetative incompatibility, suggesting that this suppressor effect is independent of the cAMP pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.