ArticleGenetics1999
Position effect variegation at the mating-type locus of fission yeast: a cis-acting element inhibits covariegated expression of genes in the silent and expressed domains.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023Review
- Satellite DNA-Mediated Gene Expression Regulation: Physiological and Evolutionary Implication.Progress in molecular and subcellular biology · 2021Article
- Article
- A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin.eLife · 2020Article
- Genomic clustering within functionally related gene families inComputational and structural biotechnology journal · 2020Review
- Article
- Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance.PLoS genetics · 2017Article
- New Insights into the Regulation of Heterochromatin.Trends in genetics : TIG · 2016Review
- Two portable recombination enhancers direct donor choice in fission yeast heterochromatin.PLoS genetics · 2013Article
- TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.Molecular and cellular biology · 2009Article
- The impact of local genome sequence on defining heterochromatin domains.PLoS genetics · 2009Article
- Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe.Genetics · 2007Article
- Article
- Stochasticity or the fatal 'imperfection' of cloning.Journal of biosciences · 2005Review
- Dynamic regulation of replication independent deposition of histone H3 in fission yeast.Nucleic acids research · 2005Article
- Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.Nucleic acids research · 2005Article
- Article
- A novel jmjC domain protein modulates heterochromatization in fission yeast.Molecular and cellular biology · 2003Article
- Article
- Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Nucleic acids research · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizosaccharomyces pombe switches its mating type by transposing a copy of unexpressed genes from the respective mat2 or mat3 cassettes to mat1. The donor cassettes are located in a silent domain that is separated from the expressed mat1 cassette by the L region. We monitored the expression of ade6 from sites in the L region and examined the relationship between the expression state at these sites and at sites within the silent domain. Results indicate that: (1) the silent domain extends into the L region, but repression is gradually alleviated with increasing distance from mat2, and overexpression of swi6 enhances PEV in the L region; (2) a transcriptionally active chromatin state, associated with reporter gene expression in the L region, spreads toward the silent domain; (3) a cis-acting element, located at the junction between the L region and mat2-P, ensures repression in the silent domain, regardless of the expression state in the L region; and (4) repression in mat1-P cells is less stringently controlled than in mat1-M cells. We discuss the functional organization of the mat region and genetic elements that ensure separation between repressed and derepressed domains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.