ArticleThe Journal of cell biology1999
The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Restoration of the GTPase activity and cellular interactions of GαScience advances · 2022Article
- Humanization ofBiomedicines · 2020Article
- Cbl-Associated Protein CAP contributes to correct formation and robust function of the Drosophila heart tube.PloS one · 2020Article
- Antagonistic PCP Signaling Pathways in the developing Drosophila eye.Scientific reports · 2018Article
- Multiple pathways mediate the sex-peptide-regulated switch in female Drosophila reproductive behaviours.Proceedings. Biological sciences · 2013Article
- Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Drosophila models of cardiac disease.Progress in molecular biology and translational science · 2011Review
- Hedgehog signaling in the normal and neoplastic mammary gland.Current drug targets · 2010Review
- Article
- Go contributes to olfactory reception in Drosophila melanogaster.BMC physiology · 2009Article
- Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling.Molecular biology of the cell · 2009Article
- Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.Developmental cell · 2008Article
- Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation.The Journal of cell biology · 2008Article
- Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation.The Journal of cell biology · 2008Article
- The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster.BMC developmental biology · 2008Article
- Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene encoding the alpha subunit of the Drosophila Go protein is expressed early in embryogenesis in the precursor cells of the heart tube, of the visceral muscles, and of the nervous system. This early expression coincides with the onset of the mesenchymal-epithelial transition to which are subjected the cardial cells and the precursor cells of the visceral musculature. This gene constitutes an appropriate marker to follow this transition. In addition, a detailed analysis of its expression suggests that the cardioblasts originate from two subpopulations of cells in each parasegment of the dorsal mesoderm that might depend on the wingless and hedgehog signaling pathways for both their determination and specification. In the nervous system, the expression of Goalpha shortly precedes the beginning of axonogenesis. Mutants produced in the Goalpha gene harbor abnormalities in the three tissues in which the gene is expressed. In particular, the heart does not form properly and interruptions in the heart epithelium are repeatedly observed, henceforth the brokenheart (bkh) name. Furthermore, in the bkh mutant embryos, the epithelial polarity of cardial cells was not acquired (or maintained) in various places of the cardiac tube. We predict that bkh might be involved in vesicular traffic of membrane proteins that is responsible for the acquisition of polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.