ArticleAntimicrobial agents and chemotherapy1999
Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 91 citations in OpenAlex.
- Effects ofInfection and immunity · 2023Article
- Sulfadiazine analogs: anti-Toxoplasma in vitro study of sulfonamide triazoles.Parasitology research · 2023Article
- Nanoformulation-Based 1,2,3-Triazole Sulfonamides for Anti-Tropical medicine and infectious disease · 2023Article
- Inhibition of signal peptidase complex expression affects the development and survival ofFrontiers in cellular and infection microbiology · 2023Article
- Comparative Surfaceome Analysis of ClonalMicroorganisms · 2022Article
- Effects of a Serine Protease Inhibitor N-Pharmaceutics · 2022Article
- [Characteristics of exosomes secreted byNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Characterization of metalloproteases and serine proteases of Toxoplasma gondii tachyzoites and their effect on epithelial cells.Parasitology research · 2019Article
- The p38 MAPK inhibitor, SB203580, inhibits cell invasion by Neospora caninum.Parasitology research · 2017Article
- Transcriptional profiling of Toll-like receptor 2-deficient primary murine brain cells during Toxoplasma gondii infection.PloS one · 2017Article
- Activation of aFrontiers in microbiology · 2017Article
- Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.Antimicrobial agents and chemotherapy · 2014Article
- Differential gene expression in mice infected with distinct Toxoplasma strains.Infection and immunity · 2012Article
- The parasite specific substitution matrices improve the annotation of apicomplexan proteins.BMC genomics · 2012Article
- Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.PloS one · 2012Article
- An atypical proprotein convertase in Giardia lamblia differentiation.Molecular and biochemical parasitology · 2011Article
- Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites.Cellular microbiology · 2010Article
- Leishmania infantum chagasi: a genome-based approach to identification of excreted/secreted proteins.Experimental parasitology · 2010Article
- Identification, purification, and characterization of a secretory serine protease in an Indian strain of Leishmania donovani.Molecular and cellular biochemistry · 2009Article
- The prodomain of Toxoplasma gondii GPI-anchored subtilase TgSUB1 mediates its targeting to micronemes.Traffic (Copenhagen, Denmark) · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of protease inhibitors on the asexual development of the protozoan parasite Toxoplasma gondii. Among the inhibitors tested only two irreversible serine protease inhibitors, 3,4-dichloroisocoumarin and 4-(2-aminoethyl)-benzenesulfonyl fluoride, clearly prevented invasion of the host cells by specifically affecting parasite targets in a dose-dependent manner, with 50% inhibitory concentrations between 1 and 5 and 50 and 100 microM, respectively. Neither compound significantly affected parasite morphology, basic metabolism, or gliding motility within the range of the experimental conditions in which inhibition of invasion was demonstrated. No partial invasion was observed, meaning that inhibition occurred at an early stage of the interaction. These results suggest that at least one serine protease of the parasite is involved in the invasive process of T. gondii.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.