ArticleApplied and environmental microbiology1999
Transcriptional control of ADH genes in the xylose-fermenting yeast Pichia stipitis.
Article in Applied and environmental microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Transcriptomic Insights into Sre1-Related Regulatory Responses to Hypoxia, Cobalt Chloride, and Clotrimazole inJournal of fungi (Basel, Switzerland) · 2026Article
- Identification of the ADH gene family in Trichosporon asahii and the role of TaADH_like in pathogenicity and fluconazole resistance.BMC genomics · 2025Article
- Review
- The draft genome sequence of3 Biotech · 2021Article
- Effects of glucose, ethanol and acetic acid on regulation of ADH2 gene from Lachancea fermentati.PeerJ · 2016Article
- Alcohol dehydrogenases from Kluyveromyces marxianus: heterologous expression in Escherichia coli and biochemical characterization.BMC biotechnology · 2014Article
- Scheffersomyces stipitis: a comparative systems biology study with the Crabtree positive yeast Saccharomyces cerevisiae.Microbial cell factories · 2012Article
- Temporal analysis of xylose fermentation by Scheffersomyces stipitis using shotgun proteomics.Journal of industrial microbiology & biotechnology · 2012Article
- Article
- Pichia stipitis genomics, transcriptomics, and gene clusters.FEMS yeast research · 2009Review
- Shuffling of promoters for multiple genes to optimize xylose fermentation in an engineered Saccharomyces cerevisiae strain.Applied and environmental microbiology · 2007Article
- Efficient production of L-lactic acid from xylose by Pichia stipitis.Applied and environmental microbiology · 2007Article
- Saccharomyces cerevisiae engineered for xylose metabolism exhibits a respiratory response.Applied and environmental microbiology · 2004Article
- Transcriptional regulation of the gene encoding an alcohol dehydrogenase in the archaeon Sulfolobus solfataricus involves multiple factors and control elements.Journal of bacteriology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the expression of the genes encoding group I alcohol dehydrogenases (PsADH1 and PsADH2) in the xylose-fermenting yeast Pichia stipitis CBS 6054. The cells expressed PsADH1 approximately 10 times higher under oxygen-limited conditions than under fully aerobic conditions when cultivated on xylose. Transcripts of PsADH2 were not detectable under either aeration condition. We used a PsADH1::lacZ fusion to monitor PsADH1 expression and found that expression increased as oxygen decreased. The level of PsADH1 transcript was repressed about 10-fold in cells grown in the presence of heme under oxygen-limited conditions. Concomitantly with the induction of PsADH1, PsCYC1 expression was repressed. These results indicate that oxygen availability regulates PsADH1 expression and that regulation may be mediated by heme. The regulation of PsADH2 expression was also examined in other genetic backgrounds. Disruption of PsADH1 dramatically increased PsADH2 expression on nonfermentable carbon sources under fully aerobic conditions, indicating that the expression of PsADH2 is subject to feedback regulation under these conditions.
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