ArticleGenes & development1999
Assembly of functionally active Drosophila origin recognition complex from recombinant proteins.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 100 citations in OpenAlex.
- Review
- Efficiency and equity in origin licensing to ensure complete DNA replication.Biochemical Society transactions · 2021Review
- HumanizedGenetics · 2020Article
- Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA.Nucleic acids research · 2020Article
- DNA Replication Control DuringGenetics · 2017Review
- Mechanisms and regulation of DNA replication initiation in eukaryotes.Critical reviews in biochemistry and molecular biology · 2017Review
- ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila.Nucleic acids research · 2016Article
- Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6.American journal of medical genetics. Part A · 2015Article
- Functional insight into the role of Orc6 in septin complex filament formation in Drosophila.Molecular biology of the cell · 2015Article
- Article
- Regulating DNA replication in eukarya.Cold Spring Harbor perspectives in biology · 2013Review
- The origin recognition complex: a biochemical and structural view.Sub-cellular biochemistry · 2012Review
- Different roles of the human Orc6 protein in the replication initiation process.Cellular and molecular life sciences : CMLS · 2011Article
- Study of DNA replication in Drosophila using cell free in vitro system.Cell cycle (Georgetown, Tex.) · 2010Article
- Functional analysis of an Orc6 mutant in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Binding of Drosophila ORC proteins to anaphase chromosomes requires cessation of mitotic cyclin-dependent kinase activity.Molecular and cellular biology · 2009Article
- Multiple mechanisms contribute to Schizosaccharomyces pombe origin recognition complex-DNA interactions.The Journal of biological chemistry · 2008Article
- The origin recognition complex is dispensable for endoreplication in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Role of the Orc6 protein in origin recognition complex-dependent DNA binding and replication in Drosophila melanogaster.Molecular and cellular biology · 2007Article
- Vectors for co-expression of an unrestricted number of proteins.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotes the sites for the initiation of chromosomal DNA replication are believed to be determined in part by the binding of a heteromeric origin recognition complex (ORC) to DNA. We have cloned the genes encoding the subunits of the Drosophila ORC. Each of the genes is unique and can be mapped to discrete chromosomal locations implying that the pattern and developmental regulation of origin usage in Drosophila is not regulated solely by a large family of different ORC proteins. The six-subunit ORC can be reconstituted with recombinant proteins into a complex that restores DNA replication in ORC-depleted Drosophila or Xenopus egg extracts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.