ArticleJournal of clinical pathology1999
Differential expression of keratins 10, 17, and 19 in normal cervical epithelium, cervical intraepithelial neoplasia, and cervical carcinoma.
Article in Journal of clinical pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.Virchows Archiv : an international journal of pathology · 2022Article
- E6/E7 Functional Differences among Two Natural Human Papillomavirus 18 Variants in Human Keratinocytes.Viruses · 2021Article
- Modeling and validating three dimensional human normal cervix and cervical cancer tissues in vitro.Journal of biomedical research · 2017Article
- Correlation of P16 (Ink4a) and CK17 to HPV (16E6+18E6) in Premalignant and Malignant Lesions of Uterine Cervix: A Clinicopathologic Study.Iranian journal of pathology · 2016Article
- Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Adenoid squamous cell carcinoma of the oral cavity.International journal of clinical and experimental pathology · 2012Article
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- A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer.PloS one · 2011Article
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- Keratin expression in endocrine organs and their neoplasms.Endocrine pathology · 2009Review
- Cytokeratin 17 mRNA expression has potential for diagnostic marker of oral squamous cell carcinoma.Journal of cancer research and clinical oncology · 2008Article
- Distribution of HPV infection and tumour markers in cervical intraepithelial neoplasia from cone biopsies of Mozambican women.Journal of clinical pathology · 2005Article
- Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.Journal of virology · 2004Article
- Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair.The EMBO journal · 2002Article
- Cytokeratin 10/13, 14, 7, 8, and 18 in invasive squamous cell carcinoma and adenocarcinoma of the uterine cervix.Journal of clinical pathology · 1999Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the value of immunohistochemistry in defining a keratin profile to aid cervical histopathological diagnosis.
methodsImmunohistochemical localisation of keratins 17, 10, and 19 was studied in 268 cervical biopsies from 216 women including normal epithelia (with and without human papilloma virus), low and high grade cervical intraepithelial neoplasia, and invasive carcinoma. The percentage of positive immunostaining was scored using a Kontron MOP videoplan image analyser.
resultsAll major categories of cervical epithelia expressed these keratins to varying degrees. The median percentage of immunostaining for keratin 10 was 40% in normal tissue compared with just 1% in invasive carcinoma (p < 0.0001). The medians for keratin 17 were 0% in the normal group and 80% in carcinomas (p < 0.0001). By contrast, there was no significant difference in staining for keratin 19. Using a combination of the keratin 10 and 17 percentages, it was possible to separate the carcinomas from the benign conditions with a sensitivity of 100% and a specificity of 93%. Further analyses within the groups revealed more extensive staining for keratins 10 and 19 in reserve cell hyperplasia, immature squamous metaplasia, and congenital transformation zone.
conclusionsThe morphological variety within the cervix is reflected, in part, by distinct keratin patterns. There are striking differences in the patterns of keratins 10 and 17 between infiltrating squamous carcinoma and normal cervical epithelia.
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