ArticleJournal of clinical pathology1999
Reduced expression of alpha catenin is associated with poor prognosis in colorectal carcinoma.
Article in Journal of clinical pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression.Oncogenesis · 2018Article
- Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells.Oncology letters · 2013Article
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- DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity.Molecular and cellular biology · 2012Article
- miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer.British journal of cancer · 2010Article
- Loss of Coxsackie and adenovirus receptor downregulates alpha-catenin expression.British journal of cancer · 2009Article
- Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.The Journal of biological chemistry · 2009Article
- Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.Seminars in cancer biology · 2008Review
- Is there a genetic signature for liver metastasis in colorectal cancer?World journal of gastroenterology · 2007Review
- Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.Cancer science · 2007Article
- Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer.Journal of clinical pathology · 2006Article
- Limited influences of chemotherapy on healthy and metastatic liver parenchyma.World journal of gastroenterology · 2005Article
- Article
- Effect of laparotomy and CO(2) pneumoperitoneum on tumor growth of human colon carcinoma and expression pattern of tumor-associated proteins in the SCID mouse.International journal of colorectal disease · 2003Article
- Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma.Journal of clinical pathology · 2001Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate alpha catenin expression in surgically resected human colorectal cancers to evaluate its prognostic value during long term follow up.
methodsImmunohistochemistry was used to compare the expression of alpha catenin with conventional prognostic factors in 187 colorectal cancer patients treated in Kuopio University Hospital and followed up for a mean of 14 years. The hypothesis that the intensity of expression of alpha catenin and its distribution in cancer cells is correlated with survival was tested with the long-rank test, hazard ratios, and their confidence intervals.
resultsUniform membranous alpha catenin staining localised to the intercellular borders was observed in 46% of the tumours; 55% of all tumours had either heterogeneous or negative alpha catenin expression, and staining intensity was either negative or weak in 42% of the tumours. The cancer related and recurrence-free survival rates were lower among patients with a weak alpha catenin intensity in tumour epithelium (p < 0.001), a low fraction of positive tumour cells (p < 0.001), and an additional cytoplasmic accumulation of alpha catenin (p < 0.001). In multivariate analysis, the intensity of alpha catenin expression in tumour epithelium predicted cancer related survival independently; alpha catenin localisation in tumour epithelium was an independent prognostic factor of recurrence-free survival in the group as a whole and in the T1-3N0M0 tumour subgroup.
conclusionsA low proportion of positive carcinoma cells, additional cytoplasmic accumulation of alpha catenin, and reduced expression intensity in tumour epithelium predict a poor survival rate. The results suggest that alpha catenin has prognostic significance in colorectal cancer.
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