ArticleAnnals of the rheumatic diseases1999
Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts.
Article in Annals of the rheumatic diseases, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Protease Activated Receptors and Arthritis.International journal of molecular sciences · 2021Review
- Thrombin promotes matrix metalloproteinase-13 expression through the PKCδ c-Src/EGFR/PI3K/Akt/AP-1 signaling pathway in human chondrocytes.Mediators of inflammation · 2013Article
- Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways.Arthritis research & therapy · 2012Article
- Distinct functions of activated protein C differentially attenuate acute kidney injury.Journal of the American Society of Nephrology : JASN · 2009Article
- Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice.Rheumatology international · 2007Article
- Expression of the peptide C4b-binding protein beta in the arthritic joint.Annals of the rheumatic diseases · 2006Article
- Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts.Arthritis research & therapy · 2005Article
- Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis.Arthritis research & therapy · 2005Article
- A fibrin based model for rheumatoid synovitis.Annals of the rheumatic diseases · 2003Review
- Role of nuclear factor kappaB in synovial inflammation.Current rheumatology reports · 2002Review
- Tissue factor as a proinflammatory agent.Arthritis research · 2002Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clarify the mechanism of thrombin receptor mediated signal transduction and the induction of cytokines by thrombin stimulation in rheumatoid synovial fibroblasts.
methodsCytokines were measured by enzyme linked immunosorbent assay (ELISA) in the supernatants of cultured rheumatoid synovial fibroblasts stimulated by thrombin. To assess the mechanism of thrombin receptor mediated signal transduction in the rheumatoid synovial fibroblasts, electrophoretic mobility gel shift assay (EMSA), immunoglobulin kappa-chloramphenicol acetyltransferase (CAT) assay, and immunostaining for NF-kappa B subunit molecule was performed.
resultsThrombin stimulation activated the inducible transcription factor NF-kappa B, and then induced subsequent expressions of interleukin 6 (IL6) and granulocyte colony stimulating factor (G-CSF) in the cells.
conclusionThrombin receptor mediated signal transduction could induce the expressions of IL6 and G-CSF, and increase inflammatory events in the cavum articulare via NF-kappa B activation.
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