ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners1999
Polypharmacy in general practice: differences between practitioners.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Knowledge of the pharmacological profile of a patient improves the quality of prescribing, the outcomes of treatment, and the utilization of health services in primary health care.European journal of clinical pharmacology · 2011Trial
- Patients' Attitudes Towards Deprescribing and Associations With Patient-Related Factors Across Two Hospital Settings.Basic & clinical pharmacology & toxicology · 2026Article
- Unwarranted variation in potentially inappropriate medication in general practice: a Danish nationwide register-based cohort study.BMJ open · 2026Article
- Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes.Pharmacoepidemiology and drug safety · 2022Article
- Prescription Rates, Polypharmacy and Prescriber Variability in Swiss General Practice-A Cross-Sectional Database Study.Frontiers in pharmacology · 2022Article
- Observational
- Drug-related problem and its predictors among pediatric patients with infectious diseases admitted to Jimma University Medical Center, Southwest Ethiopia: Prospective observational study.SAGE open medicine · 2020Article
- Drug-Related Problems and Their Predictors Among Patients with Diabetes Attending the Ambulatory Clinic of Gebre Tsadik Shawo General Hospital, Southwest Ethiopia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- The prevalence and determinants of polypharmacy at age 69: a British birth cohort study.BMC geriatrics · 2018Article
- Polypharmacy Among the Elderly in a List-Patient System.Drugs - real world outcomes · 2015Article
- Assessing the impact of national antibiotic campaigns in Europe.The European journal of health economics : HEPAC : health economics in prevention and care · 2013Article
- Geographical differences in the prevalence of chronic polypharmacy in older people: eleven years of the EPIFARM-Elderly Project.European journal of clinical pharmacology · 2013Article
- A population-based study on the association between acute renal failure (ARF) and the duration of polypharmacy.BMC nephrology · 2012Article
- Psychiatrist characteristics related to patient outcome in Japan.The Psychiatric quarterly · 2012Article
- Prevalence and risk of polypharmacy among the elderly in an outpatient setting: a retrospective cohort study in the Emilia-Romagna region, Italy.Drugs & aging · 2010Article
- Anti-psychotic drug prescription pattern for schizophrenia: Observation from a general hospital psychiatry unit.Indian journal of psychiatry · 2010Article
- Determinants of the range of drugs prescribed in general practice: a cross-sectional analysis.BMC health services research · 2007Article
- Pharmaceutical care and its relationship to prescribing behaviour of general practitioners.Pharmacy world & science : PWS · 2006Article
- Therapeutic drug monitoring of atazanavir: surveillance of pharmacotherapy in the clinic.British journal of clinical pharmacology · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolypharmacy, the simultaneous use of multiple drugs, is associated with adverse drug reactions, medication errors, and increased risk of hospitalization. When the number of concurrently used drugs totals five or more (major polypharmacy), a significant risk may be present.
aimTo analyse the interpractice variation in the prevalence of major polypharmacy among listed patients, and to identify possible predictors of major polypharmacy related to the practice.
methodPrescription data were retrieved from the Odense Pharmacoepidemiological Database, and individuals subject to major polypharmacy were identified. The age- and sex-standardized prevalence rate of major polypharmacy was calculated for each practice in the County of Funen in Denmark (n = 173), using the distribution of age and sex of the background population as a reference. The practice characteristics were retrieved from the Regional Health Insurance System. Possible predictors of major polypharmacy related to the general practitioners (GPs) were analysed using backward stepwise linear multiple regression.
resultsA six-fold variation between the practices in the prevalence of major polypharmacy was found (16 to 96 per 1000 listed patients; median = 42). Predictors related to the practice structure, workload, clinical work profile, and prescribing profile could explain 56% of the variation.
conclusionA substantial part of the variation in major polypharmacy between practices can be explained by predictors related to practice.
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10343422PMC1313371What OpenQuestion holds
Registered trials
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