ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Neuroprotection at Drosophila synapses conferred by prior heat shock.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 108 citations in OpenAlex.
- Peripheral modulation of Pumilio in intestinal stem cells and the corpus allatum affects sleep latency in Drosophila.PloS one · 2026Article
- Three Heat Shock Protein Genes and Antioxidant Enzymes ProtectInternational journal of molecular sciences · 2022Article
- Acute Effect of Exposure to Extreme Heat (100 ± 3 °C) on Lower Limb Maximal Resistance Strength.International journal of environmental research and public health · 2022Article
- Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation.International journal of molecular sciences · 2022Article
- Neural functions of small heat shock proteins.Neural regeneration research · 2022Review
- Modulation of neuromuscular excitability in response to acute noxious heat exposure has no additional effects on central and peripheral fatigability.Frontiers in physiology · 2022Article
- PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress inInternational journal of molecular sciences · 2020Article
- Small heat shock proteins determine synapse number and neuronal activity during development.PloS one · 2020Article
- Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol.Cell stress & chaperones · 2016Article
- Article
- Heat shock response and homeostatic plasticity.Frontiers in cellular neuroscience · 2015Article
- Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol.Cell stress & chaperones · 2014Article
- Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons.BioMed research international · 2014Article
- Hot ambient conditions shift the Force / EMG relationship.SpringerPlus · 2013Article
- Temperature affects maximum H-reflex amplitude but not homosynaptic postactivation depression.Physiological reports · 2013Article
- Neuronal responses to physiological stress.Frontiers in genetics · 2012Article
- Temperature dependent plasticity of habituation in the crayfish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Multifaceted role of heat shock protein 70 in neurons.Molecular neurobiology · 2010Review
- Hyperthermia impairs short-term memory and peripheral motor drive transmission.The Journal of physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapses are critical sites of information transfer in the nervous system, and it is important that their functionality be maintained under stressful conditions to prevent communication breakdown. Here we show that synaptic transmission at the Drosophila larval neuromuscular junction is protected by prior exposure to heat shock that strongly induces expression of heat shock proteins, in particular hsp70. Using a macropatch electrode to record synaptic activity at individual, visualized boutons, we found that prior heat shock sustains synaptic performance at high test temperatures through pre- and postsynaptic alterations. After heat shock, nerve impulses release more quantal units at high temperatures and exhibit fewer failures of release (presynaptic modification), whereas the amplitude of quantal currents remains more constant than does that in nonheat-shocked controls (postsynaptic modification). The time course of these physiological changes is similar to that of elevated hsp70. Thus, stress-induced neuroprotective mechanisms maintain function at synapses by modifying their properties.
Indexed as
Identifiers
10341239PMC6782588W1675038283What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.