ArticleOncogene1999
Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 107 citations in OpenAlex.
- Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line.Bioengineered · 2024Article
- Liver function and energy metabolism in hepatocellular carcinoma developed in patients with hepatitis B-related cirrhosis.Medicine · 2019Observational
- ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage.Oncogenesis · 2019Article
- PinX1: structure, regulation and its functions in cancer.Oncotarget · 2016Review
- Genomic losses at 5q13.2 and 8p23.1 in dysplastic hepatocytes are common events in hepatitis B virus-related hepatocellular carcinoma.Oncology letters · 2015Article
- TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma.Molecular cancer · 2015Article
- The suppressive role of SOX7 in hepatocarcinogenesis.PloS one · 2014Article
- Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway by influencing β-catenin in hepatocellular carcinoma.Oncogene · 2012Article
- Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review).International journal of oncology · 2012Review
- Article
- Dickkopfs and Wnt/β-catenin signalling in liver cancer.World journal of clinical oncology · 2011Article
- The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.The Journal of clinical investigation · 2011Article
- DLC-1 as a modulator of proliferation, apoptosis and migration in Burkitt's lymphoma cells.Molecular biology reports · 2011Article
- Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.Nature cell biology · 2010Article
- Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.The Journal of clinical investigation · 2010Article
- TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies.European journal of pharmacology · 2009Review
- TRAIL gene therapy: from preclinical development to clinical application.Current gene therapy · 2009Review
- Frequent loss of heterozygosity in two distinct regions, 8p23.1 and 8p22, in hepatocellular carcinoma.World journal of gastroenterology · 2007Article
- Genetics of hepatocellular tumors.Oncogene · 2006Review
- LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma.Oncogene · 2004Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromosome 8p is associated with a large number of allelic imbalances in epithelial tumors including hepatocellular carcinoma (HCC). However, no tumor suppressor gene has been identified so far in this particular region of the genome. To further clarify the pattern of allelic deletions on chromosome 8p in HCC, we have undertaken high-density polymorphic marker analysis of 109 paired normal and primary tumor samples using 40 microsatellites positioned every 2 cm in average throughout 8p. We found that 60% of the tumors exhibited loss of heterozygosity (LOH) at one or more loci at 8p with three distinct minimal deleted areas: a 13 cm region in the distal part of 8p21, a 9 cm area in the more proximal portion of 8p22 and a 5 cm area in 8p23. These data strongly suggest the presence of at least three novel tumor suppressor loci on 8p in hepatocellular carcinoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.